Glucuronic Acid (Glucuronate)

A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.

Also Known As:

Networked: 265 relevant articles (3 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Barycki, Joseph J: 2 articles (09/2021 - 01/2016)
2.	Howell, Michelle E: 2 articles (09/2021 - 01/2016)
3.	Ma, Linlin: 2 articles (09/2021 - 01/2016)
4.	Simpson, Melanie A: 2 articles (09/2021 - 01/2016)
5.	Zimmer, Brenna M: 2 articles (09/2021 - 01/2016)
6.	Campbell, Kevin P: 2 articles (01/2021 - 11/2013)
7.	Li, Bowen: 2 articles (01/2021 - 01/2021)
8.	Esko, Jeffrey D: 2 articles (01/2020 - 05/2007)
9.	Borsig, Lubor: 2 articles (06/2019 - 05/2007)
10.	Mourão, Paulo A S: 2 articles (06/2019 - 05/2007)

Related Diseases

1.	Alcoholic Fatty Liver 08/01/2000 - "In conclusion, the 8-week treatment with betaine glucuronate combined with diethanolamine glucuronate and nicotinamide ascorbate was found effective in non-alcoholic steatohepatitis, a disorder for which the hitherto pharmacological interventions were poorly and inconsistently effective."
2.	Epilepsy (Aura) 01/01/1994 - "Lorazepam (LZP), which is primarily eliminated by conjugation with glucuronic acid, is administered concurrently with VPA both in treatment of epilepsy and in patients treated with VPA for psychiatric disorders. "
3.	Mental Disorders (Mental Disorder) 01/01/1994 - "Lorazepam (LZP), which is primarily eliminated by conjugation with glucuronic acid, is administered concurrently with VPA both in treatment of epilepsy and in patients treated with VPA for psychiatric disorders. "
4.	Hypoxia (Hypoxemia) 06/01/1973 - "In half isotonic solutions reflectance was reduced by 31%.3. Anoxia led to a decreased reflectance which was eliminated if all the Cl was substituted by the larger glucuronate anion.4. It is concluded that slice reflectance is lowered when cellular volumes are increased by water or isotonic solution influx.5. Membrane depolarization effected by ouabain, high (60 mM) K bathing medium, veratridine or repeated electrical pulses led to rapid decreases in reflectance of 25, 27, 31 and 7.5% respectively. "
5.	Neoplasms (Cancer) 07/10/1963 - "[STUDIES ON IMPROVEMENT OF METABOLIC CHANGES IN MALIGNANCIES, ESPECIALLY IN REGARD TO GLUCURONIC ACID METABOLISM]." 10/01/2011 - "Synthesis of some novel D-glucuronic acid acetylated derivatives as potential anti-tumor agents." 10/01/1979 - "Free glucuronic acid in urine as estimate of tumor load." 10/01/1965 - "Studies on the changes of serum beta-glucuronidase activity of the cancer hosts and the mechanism of inhibiting effects of glucuronic acid and the related substances upon the glucuronidase activities." 08/01/2022 - "Levels of norvaline, glucuronate and galacturonate were lower in the cancer group than in the Control (p < 0.05). "

Related Drugs and Biologics

1.	Solutions
2.	Niacinamide (Nicotinamide)
3.	Anions
4.	Veratridine
5.	Ouabain (G Strophanthin)
6.	Lorazepam (Ativan)
7.	Isotonic Solutions
8.	betaine glucuronate
9.	diethanolamine
10.	Bilirubin

Related Therapies and Procedures

1.	Therapeutics
2.	Spinal Injections
3.	Intraperitoneal Injections
4.	Intravenous Infusions
5.	Aftercare (After-Treatment)