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Chiral Molecule-mediated Porous Cu xO Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson's Disease.

Abstract
Reactive oxygen species (ROS)-mediated mitochondrial dysfunction is one of the major pathological mechanisms of Parkinson's disease. Using inorganic nanomaterials to scavenge ROS has drawn significant interest and can prevent ROS-mediated neurological disorders. We prepared uniform Cu xO nanoparticle clusters (NCs) with an average size of 65 ± 7 nm, using phenylalanine (Phe) as the structure-directing agent. These Cu xO NCs functionally mimicked the activities of peroxidase, superoxide dismutase, catalase, and glutathione peroxidase. Because they eliminated ROS, the Cu xO NCs inhibited neurotoxicity in a cellular model of Parkinson's disease and rescued the memory loss of mice with Parkinson's disease. The biocompatibility and multiple enzyme-mimicking activities of Cu xO NCs offer new opportunities for the application of NCs in biomedicine, biosensing, and biocatalysis.
AuthorsChanglong Hao, Aihua Qu, Liguang Xu, Maozhong Sun, Hongyu Zhang, Chuanlai Xu, Hua Kuang
JournalJournal of the American Chemical Society (J Am Chem Soc) Vol. 141 Issue 2 Pg. 1091-1099 (01 16 2019) ISSN: 1520-5126 [Electronic] United States
PMID30540450 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Video-Audio Media)
Chemical References
  • Antiparkinson Agents
  • Free Radical Scavengers
  • Nootropic Agents
  • Reactive Oxygen Species
  • Copper
Topics
  • Animals
  • Antiparkinson Agents (chemical synthesis, therapeutic use)
  • Brain (pathology)
  • Catalysis
  • Cell Line, Tumor
  • Copper (chemistry, therapeutic use)
  • Free Radical Scavengers (chemical synthesis, therapeutic use)
  • Humans
  • Maze Learning (drug effects)
  • Memory (drug effects)
  • Metal Nanoparticles (chemistry, therapeutic use)
  • Mice
  • NIH 3T3 Cells
  • Nootropic Agents (chemical synthesis, therapeutic use)
  • Oxidative Stress (drug effects)
  • Parkinson Disease (drug therapy, pathology)
  • Reactive Oxygen Species (metabolism)

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