A Natural Phenolic Compound Quercetin Showed the Usefulness by Targeting Inflammatory, Oxidative Stress Markers and Augment 5-HT Levels in One of the Animal Models of Depression in Mice.

Abstract

AIM:

In the present study quercetin was studied for its role in inflammation, oxidative stress markers and 5-HT levels in unpredictable chronic mild stress (UCMS) animal model of depression.

MATERIALS AND METHODS:

The mice were randomized into different groups trained for UCMS protocol followed by different drug treatments. Treatments were started after 2 weeks from the start of UCMS protocol and continued up to 6 weeks. The behavioral tests such as modified forced swimming (MFST), tail suspension (TST) and open field tests were performed on week 6, at least 24 h after the last drug treatment. Behavioral tests were preceded following animal sacrifice for biochemical estimations.

RESULTS:

A significant decrease in swimming, climbing times and increase in immobility time in MFST and TST was observed in UCMS group. Administration of quercetin (25 mg/kg per orally (p.o) reversed these times in MFST and TST. A decrease in no. of field crossing, time spent in centre and no. of rearing were observed in UCMS group. Quercetin reduced these observations in open field test. There was a decrease in superoxide dismutase (SOD), glutathione (GSH), catalase and 5 HT levels in the brain tissue. Quercetin treatment significantly augmented SOD, GSH, catalase and 5 HT levels. Glutamate, TNF-α and IL-6 levels were increased in UCMS group while quercetin decreased these cytokines.

CONCLUSION:

Quercetin resulted antidepressant-like effect by its antioxidant, anti-inflammatory activities, reduced excitotoxicity and augmented 5 HT levels. This pointed out the usefulness of this phenolic compound as adjuvent drug along with other antidepressant drugs.

• Authors: Khadeeja Khan, Abul Kalam Najmi, Mohd Akhtar
• Journal: Drug research (Drug Res (Stuttg)) Vol. 69 Issue 7 Pg. 392-400 (Jul 2019) ISSN: 2194-9387 [Electronic] Germany
• PMID: 30296804 (Publication Type: Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Anti-Inflammatory Agents
• Antidepressive Agents
• Antioxidants
• Biomarkers
• Serotonin
• Quercetin

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Antidepressive Agents (pharmacology, therapeutic use)
• Antioxidants (pharmacology, therapeutic use)
• Behavior, Animal (drug effects)
• Biomarkers (analysis, metabolism)
• Brain (drug effects, immunology, pathology)
• Depression (drug therapy, etiology, pathology)
• Disease Models, Animal
• Humans
• Inflammation (drug therapy, pathology)
• Male
• Mice
• Oxidative Stress (drug effects)
• Quercetin (pharmacology, therapeutic use)
• Serotonin (analysis, metabolism)
• Stress, Psychological (complications)
• Treatment Outcome