Abstract | OBJECTIVES: METHODS: Participants with (n=209) and without (n=244) type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study were assessed for serum copeptin, vitals, estimated glomerular filtration rate, urinary albumin-to- creatinine ratio, glycated hemoglobin and lipid panels. Estimated insulin sensitivity (eIS) was calculated by validated equations in participants with and without type 1 diabetes. The relationships among copeptin, IR, waist circumference (WC) and body mass index (BMI) were examined with unadjusted and adjusted linear regression models. RESULTS: Copeptin was correlated with eIS (R=-0.17, R2=0.029), WC (R=0.16, R2=0.026) and BMI (R=0.22, R2=0.048) for type 1 diabetes and with eIS (R=-0.37, R2=0.14), WC (R=0.40, R2=0.16) and BMI (R=0.25, R2=0.063) in non- type 1 diabetes. In multivariable analysis, copeptin correlated with total cholesterol (beta±SE: -0.12±0.04, p=0.008) and low-density lipoprotein (beta±SE: -0.11±0.04, p=0.01) in type 1 diabetes. In non- type 1 diabetes, copeptin was associated with WC (beta±SE: 0.14±0.04, p=0.0024), BMI (beta±SE: 0.13±0.04, p=0.007) and eIS (beta±SE: -0.14±0.04, p=0.0013). CONCLUSIONS:
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Authors | Thomas Jensen, Petter Bjornstad, Richard J Johnson, Rachel Sippl, Marian Rewers, Janet K Snell-Bergeon |
Journal | Canadian journal of diabetes
(Can J Diabetes)
Vol. 43
Issue 1
Pg. 34-39
(Feb 2019)
ISSN: 2352-3840 [Electronic] Canada |
PMID | 30026043
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Copyright | Copyright © 2018 Diabetes Canada. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Glycopeptides
- copeptins
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Topics |
- Adult
- Biomarkers
(blood)
- Coronary Artery Disease
(blood, diagnosis, epidemiology)
- Cross-Sectional Studies
- Diabetes Mellitus, Type 1
(blood, diagnosis, epidemiology)
- Female
- Glycopeptides
(blood)
- Humans
- Insulin Resistance
(physiology)
- Male
- Middle Aged
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