Embelin inhibits abdominal aortic aneurysm through decreasing IL‑6‑induced STAT3 and NF‑κB inactivation.

Abstract

The aim of the present study was to investigate the effect of embelin on abdominal aortic aneurysm (AAA). AAA model mice were induced by chronic infusion of 1,000 ng/kg/min Angiotensin II. AAA model mice were treated with 25, 50 or 100 mg/kg embelin for 28 days. Embelin inhibited tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6, IL‑18 and malondialdehyde (MDA) level activities, increased superoxide dismutase, glutathione (GSH) and GSH peroxidase level activities and inhibited MDA level activities in AAA mice Embelin suppressed the secretion of matrix metalloproteinase‑9 protein expression, monocyte chemoattractant protein‑2 activity and epithelial neutrophil‑activating peptide expression levels in AAA mice. Embelin suppressed phosphorylated‑signal transducer and activator of transcription (STAT) 3, phosphorylated‑p38 mitogen‑activated protein kinase and nuclear factor (NF)‑κB protein expression in AAA mice. These findings indicate that embelin inhibits AAA through decreasing IL‑6‑induced STAT3, and NF‑κB inactivation.

• Authors: Qiang Liu, Qingshan Wang, Haibin Li
• Journal: Molecular medicine reports (Mol Med Rep) Vol. 18 Issue 2 Pg. 2365-2372 (Aug 2018) ISSN: 1791-3004 [Electronic] Greece
• PMID: 29956759 (Publication Type: Journal Article)

Chemical References

• Benzoquinones
• Interleukin-6
• NF-kappa B
• STAT3 Transcription Factor
• Stat3 protein, mouse
• interleukin-6, mouse
• Angiotensin II
• Glutathione Peroxidase
• Glutathione
• embelin

Topics

• Angiotensin II (metabolism, pharmacology)
• Animals
• Aortic Aneurysm, Abdominal (drug therapy, genetics, pathology)
• Benzoquinones (administration & dosage)
• Disease Models, Animal
• Gene Expression Regulation (drug effects)
• Glutathione (genetics)
• Glutathione Peroxidase (genetics)
• Humans
• Interleukin-6 (genetics)
• Mice
• NF-kappa B (genetics)
• Phosphorylation (drug effects)
• STAT3 Transcription Factor (genetics)