Are heterozygous carriers for hereditary fructose intolerance predisposed to metabolic disturbances when exposed to fructose?
Abstract | Background: Objective: Design: Eight subjects heterozygous for HFI (hHFI; 4 men, 4 women) and 8 control subjects received a low- fructose diet for 7 d and on the eighth day ingested a test meal, calculated to provide 25% of the basal energy requirement, containing 13C-labeled fructose (0.35 g/kg), glucose (0.35 g/kg), protein (0.21 g/kg), and lipid (0.22 g/kg). Glucose rate of appearance (GRa, calculated with [6,6-2H2] glucose), fructose, net carbohydrate, and lipid oxidation, and plasma triglyceride, uric acid, and lactate concentrations were monitored over 6 h postprandially. Results: Postprandial GRa, fructose, net carbohydrate, and lipid oxidation, and plasma lactate and triglyceride concentrations were not significantly different between the 2 groups. Postprandial plasma uric acid increased by 7.2% compared with fasting values in hHFI subjects (P < 0.01), but not in control subjects (-1.1%, ns). Conclusions: Heterozygous carriers of hereditary fructose intolerance had no significant alteration of postprandial fructose metabolism compared with control subjects. They did, however, show a postprandial increase in plasma uric acid concentration that was not observed in control subjects in responses to ingestion of a modest amount of fructose. This trial was registered at the US Clinical Trials Registry as NCT02979106.
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Authors | François-Guillaume Debray, Katarina Damjanovic, Robin Rosset, Lauréane Mittaz-Crettol, Clothilde Roux, Olivier Braissant, Frédéric Barbey, Luisa Bonafé, Jean-Pascal De Bandt, Luc Tappy, Nicolas Paquot, Christel Tran |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 108
Issue 2
Pg. 292-299
(08 01 2018)
ISSN: 1938-3207 [Electronic] United States |
PMID | 29955837
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Uric Acid
- Fructose
- Creatinine
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Topics |
- Adult
- Carbohydrate Metabolism
- Creatinine
(blood, urine)
- Female
- Fructose
(administration & dosage, metabolism)
- Fructose Intolerance
(genetics, metabolism)
- Heterozygote
- Humans
- Lipid Metabolism
- Male
- Metabolic Diseases
(etiology)
- Uric Acid
(blood, urine)
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