Abstract |
Interleukin (IL)-36γ is expressed by keratinocytes and functions as a key initiator of inflammation in the skin. IL-36γ expression is enhanced by tumor necrosis factor-α and IL-17A, having a strong association with psoriasis. In this study, we examined the role of IL-36γ in atopic dermatitis (AD) and mycosis fungoides (MF)/Sézary syndrome (SS). Serum levels of IL-36γ in AD patients and MF/SS patients were elevated compared with those of healthy controls. Importantly, serum IL-36γ levels in AD patients positively correlated with Eczema Area and Severity Index and those of MF/SS patients positively correlated with serum soluble IL-2 receptor levels. IL-36γ mRNA levels in AD skin and MF/SS skin were significantly higher than those of normal skin. IL-36γ mRNA levels in MF/SS skin positively correlated with IL-17A mRNA levels. Immunohistochemical staining revealed that IL-36γ was highly expressed in keratinocytes in lesional skin of AD and MF/SS. Taken together, our study demonstrated that IL-36γ expression was increased in sera and skin of patients with AD and MF/SS as was reported in psoriatic patients.
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Authors | Sayaka Otobe, Makoto Sugaya, Rina Nakajima, Tomonori Oka, Naomi Takahashi, Miyoko Kabasawa, Tomomitsu Miyagaki, Yoshihide Asano, Shinichi Sato |
Journal | The Journal of dermatology
(J Dermatol)
Vol. 45
Issue 4
Pg. 468-471
(Apr 2018)
ISSN: 1346-8138 [Electronic] England |
PMID | 29314201
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2018 Japanese Dermatological Association. |
Chemical References |
- IL36G protein, human
- Interleukin-1
- RNA, Messenger
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Topics |
- Adult
- Aged
- Dermatitis, Atopic
(blood, pathology)
- Female
- Humans
- Interleukin-1
(analysis, genetics)
- Keratinocytes
(pathology)
- Male
- Middle Aged
- Mycosis Fungoides
(blood, pathology)
- RNA, Messenger
(analysis)
- Severity of Illness Index
- Sezary Syndrome
(blood, pathology)
- Skin
(cytology, pathology)
- Skin Neoplasms
(blood, pathology)
- Young Adult
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