Persisting Ulcerating Lesions After Cyclosporine Therapy for Erosions Found in Flexural Sites.

Abstract

In February 2012, a patient with a 15-year history of painful, pruritic eruptions presented with a severe exacerbation that had lasted for the previous week. The patient also reported severe headaches, a fever of 38.9°C (102.1°F), a cough, and diarrhea, which had now resolved. Physical examination showed erythematous macerated patches with erosions in the left submammary region, bilateral axillae, and vaginal area (Figure 1), and greasy scale covering the scalp. Despite lessening of the lesions in the submammary region and abdomen with the administration of minocycline 100 mg twice per day and cyclosporine 100 mg three times per day, the patient continued to complain of persistent painful ulcerations in the labia majora and perianal area (Figure 2). The patient was started on acyclovir 400 mg three times per day for 10 days for positive herpes simplex viral culture and ampicillin for Proteus infection of the area.

• Authors: Mina Amin, Shannon Famenini, Jashin J Wu
• Journal: Skinmed (Skinmed) 2017 Vol. 15 Issue 6 Pg. 474-475 ISSN: 1540-9740 [Print] United States
• PMID: 29282191 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dermatologic Agents
• Cyclosporine

Topics

• Axilla
• Breast
• Cyclosporine (therapeutic use)
• Dermatologic Agents (therapeutic use)
• Female
• Humans
• Kaposi Varicelliform Eruption (complications, drug therapy)
• Pemphigus, Benign Familial (complications, drug therapy)
• Skin Ulcer (drug therapy, etiology)
• Treatment Failure
• Vagina