Abstract | CONTEXT:
Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting of dead or dying adipocytes encircled by macrophages. In humans, bariatric surgery-induced weight loss leads to a decrease in CLSs, but the effects of rapid diet-induced weight loss on CLSs and metabolism are unclear. OBJECTIVE: DESIGN: Prospective cohort study. SETTING: Rockefeller University Hospital, New York, NY. PARTICIPANTS: Ten obese, postmenopausal women with a mean age of 60.6 years (standard deviation, ±3.6 years). MAIN OUTCOME MEASURES: Effects on CLS density and gene expression in abdominal subcutaneous adipose tissue, cardiometabolic risk factors, white blood count, circulating metabolites, and oxidative stress (urinary isoprostane-M) were measured. RESULTS: CONCLUSION: Rapid weight loss stimulated lipolysis and an increase in CLS density in subcutaneous adipose tissue in association with changes in levels of circulating metabolites, and improved systemic biomarkers of inflammation and insulin resistance. The observed change in levels of metabolites (i.e., lactate, β-hydroxybutyrate, 25 hydroxyvitamin D) may contribute to the anti-inflammatory effect of rapid weight loss.
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Authors | José O Alemán, Neil M Iyengar, Jeanne M Walker, Ginger L Milne, Joel Correa Da Rosa, Yupu Liang, Dilip D Giri, Xi Kathy Zhou, Michael N Pollak, Clifford A Hudis, Jan L Breslow, Peter R Holt, Andrew J Dannenberg |
Journal | Journal of the Endocrine Society
(J Endocr Soc)
Vol. 1
Issue 6
Pg. 625-637
(Jun 01 2017)
ISSN: 2472-1972 [Print] United States |
PMID | 29264516
(Publication Type: Journal Article)
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