Malignant gliomas are glial-derived,
primary brain tumors that carry poor prognosis. Existing
therapeutics are largely ineffective and dramatically affect quality of life. The standard of care details a taxing combination of surgical resection, radiation of the resection cavity, and
temozolomide (TMZ)
chemotherapy, with treatment extending life by only an average of months (Maher et al., 2001; Stupp et al., 2005). Despite scientific and technological advancement, surgery remains the most important treatment modality. Therapeutic obstacles include
xenobiotic protection conveyed by the blood-brain barrier (Zhang et al., 2015), invasiveness and therapeutic resistance of
tumor cell populations (Bao et al., 2006), and distinctive attributes of secondary
glioma occurrence (Ohgaki and Kleihues, 2013). While these brain
malignancies can be classified by grade or grouped by molecular subclass, each
tumor presents itself as its own complication. Based on all of these obstacles, new therapeutic approaches are urgently needed. These will likely emerge from numerous exciting studies of
glioma biology that are ongoing and reviewed here. These show unexpected roles for
ion channels,
amino-acid transporters, and
connexin gap junctions in supporting the invasive growth of
gliomas. These studies have identified a number of
proteins that may be targeted for
therapy in the future.