Abstract | BACKGROUND: METHODS: Permanent middle cerebral artery occlusion (pMCAO) was established via the suture method, followed by intravenous STVNa (7.5, 15, 30, 45, and 60 mg/kg). Neurobehavioral deficits, infarct volume, and histology were examined 24 hours after cerebral ischemia. In addition, the messenger RNA ( mRNA) expression of NF-κB-related genes was detected using real-time quantitative polymerase chain reaction (qPCR). RESULTS: CONCLUSIONS: These findings demonstrate a neuroprotective role of STVNa during cerebral ischemia, which may result from interactions with the NF-κB signaling pathway and the associated inflammatory and apoptotic responses.
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Authors | Hao Zhang, Xiaoou Sun, Yanxiang Xie, Jie Zan, Wen Tan |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 26
Issue 11
Pg. 2603-2614
(Nov 2017)
ISSN: 1532-8511 [Electronic] United States |
PMID | 28784277
(Publication Type: Journal Article)
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Copyright | Copyright © 2017. Published by Elsevier Inc. |
Chemical References |
- Cytokines
- Diterpenes, Kaurane
- Glial Fibrillary Acidic Protein
- NF-kappa B
- Neuroprotective Agents
- isosteviol
- Caspase 3
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Topics |
- Animals
- Apoptosis
(drug effects)
- Brain Injuries
(etiology, prevention & control)
- Brain Ischemia
(complications)
- Caspase 3
(metabolism)
- Cerebrovascular Circulation
(drug effects)
- Cytokines
(metabolism)
- Disease Models, Animal
- Diterpenes, Kaurane
(therapeutic use)
- Gene Expression Regulation, Enzymologic
(drug effects)
- Glial Fibrillary Acidic Protein
(metabolism)
- Inflammation
(drug therapy, etiology)
- Male
- Mice
- Mice, Inbred C57BL
- NF-kappa B
(genetics, metabolism)
- Neurologic Examination
- Neuroprotective Agents
(therapeutic use)
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