The Balance of Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Autoimmune Inner Ear Disease Patients.

Abstract

Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a protein implicated in the control of inflammation in a number of autoimmune diseases. We hypothesized that the balance of TIMP-1 and matrix metalloproteinase-9 (MMP-9) may influence the control or perpetuation of inflammation in corticosteroid-responsive (RES) and corticosteroid-resistant (NR) autoimmune inner ear disease (AIED) patients. In the present study, we observed that plasma from AIED patients exhibited greater levels of TIMP-1 values compared with normal healthy controls. TIMP-1 abrogates lipopolysaccharide-mediated interleukin (IL)-1β release from peripheral blood mononuclear cells in a dose-dependent manner. RES AIED patients have higher basal TIMP-1 levels and produce more TIMP-1 in response to IL-1β. Conversely, consistent with our previous studies, we found that NR patients have higher basal MMP-9 levels and produce more MMP-9 levels in response to IL-1β.

• Authors: Logan Eisner, Andrea Vambutas, Shresh Pathak
• Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research (J Interferon Cytokine Res) Vol. 37 Issue 8 Pg. 354-361 (08 2017) ISSN: 1557-7465 [Electronic] United States
• PMID: 28696822 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Adrenal Cortex Hormones
• Interleukin-1beta
• Tissue Inhibitor of Metalloproteinase-1
• Matrix Metalloproteinase 9

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Aged
• Autoimmune Diseases (blood, drug therapy, metabolism)
• Cellular Microenvironment
• Female
• Humans
• Inflammation (pathology)
• Interleukin-1beta (blood)
• Labyrinth Diseases (blood, drug therapy, metabolism)
• Male
• Matrix Metalloproteinase 9 (metabolism)
• Middle Aged
• Tissue Inhibitor of Metalloproteinase-1 (blood, metabolism)