Labyrinth Diseases

01/01/2002 - "Treatment of vascular inner ear disease in vascular patients with pentoxifylline: a controlled, randomized trial."
01/01/2002 - "Treatment of vascular inner ear disease with pentoxifylline: a 4-week, controlled, randomized trial."
01/01/2002 - "The efficacy of pentoxifylline (PXF) in vascular inner ear disease (VIED) was studied comparing PXF and placebo in a 4-week study; 60 patients with unilateral loss of hearing, vertigo, dizziness, tinnitus (analyzed with an analogue scale line), and cochlear flow reduction were included. "
01/01/2002 - "The efficacy of Pentoxifylline in vascular inner ear disease (VIED) was studied comparing PXF and placebo in a 4-week study; 40 patients with vascular disease and monolateral loss of hearing, vertigo, dizziness, tinnitus (analyzed with an analogue scale line), and cochlear flow reduction were included. "

01/01/1997 - "The results in the present study with proteins extracted from guinea pig inner ear were consistent with our previous study using proteins from human inner ear, suggesting that the 28-kD protein may be a candidate for detecting autoimmune inner-ear disease."
01/01/2014 - "Future research on structure and function of zona pellucida-like domain proteins will enhance our knowledge of inner ear diseases, like sudden loss of vestibular function and other disturbances. "
01/01/1997 - "Sera from patients with various inner-ear diseases, especially Ménière's disease, were investigated by Western blot against guinea pig inner-ear proteins. "
02/01/2006 - "Sera from 9 patients with DEH, 18 patients with profound unilateral juvenile hearing loss and 15 control volunteer without inner ear diseases were investigated by means of Western blot assay against rat inner ear proteins. "
01/01/1997 - "Of 45 patients, 24 (53%) with various inner-ear diseases had antibodies against inner-ear proteins, compared with 0 of 10 (0%) in control subjects without inner-ear diseases. "

10/01/2014 - "An open label study to evaluate the safety and efficacy of intratympanic golimumab therapy in patients with autoimmune inner ear disease."
10/01/2014 - "To evaluate the safety and efficacy of intratympanically injected golimumab (GLM), a TNF-α inhibitor, as a steroid-sparing agent for patients with steroid-dependent autoimmune inner ear disease (AIED). "

08/01/2012 - "The diagnosis of autoimmune inner ear disease is based either on clinical criteria or on a positive response to steroids. "
02/01/2011 - "Children with autoimmune inner ear disease seem to benefit from treatment with steroids and/or cytotoxic medication. "
12/01/2003 - "These findings suggest that the intra-endolymphatic sac steroids could make regulatory effects on the inner ear AQP-3 expression via vestibular aqueduct and modulate the homeostasis of endolymphatic fluids, encouraging the possibility that the endolymphatic sac could be a therapeutic window for the inner ear disease."
03/01/2002 - "It is highly likely that this slow elimination is closely related to the therapeutic effect of steroids in inner ear diseases."
11/01/2006 - "Audiometry revealed recovered acoustic sensation in the right ear, from 50 dB to 20 dB, and in the left ear from 70 to 35 dB with 1,000 Hz. Topical ocular drug delivery of steroids may be effective for inner ear disease and sinusitis in patients with systemic side effects to oral steroids."

11/01/1997 - "Immunoglobulin staining was conducted in cochlear tissue from the C3H/lpr autoimmune strain mouse to better understand the local immune processes underlying autoimmune inner ear disease. "
09/01/1997 - "Involvement of autoimmune mechanisms in sudden-onset, rapidly progressive, bilateral inner ear disease is supported by the following evidence: (1) the inner ear contains immune cells and mediators (immunoglobulins); (2) animal models demonstrate inner ear damage after immunization with inner ear tissue; (3) experimental autoimmune inner ear disease appears to be transferable with sensitized T cells; (4) human SNHL can occur in the context of systemic immunologic disease; (5) SNHL can be improved by immunosuppressive therapy; and (6) patients with SNHL demonstrate elevated immune responses to inner ear proteins/tissue preparations. "
12/01/1992 - "The sera of 21 patients with inner ear disease were examined for the presence of anticollagen and anticochlear antibodies; the sera were used to probe Western blots of purified human collagens II, IX, and XI, and cochlear protein extract with peroxidase-conjugated goat anti human polyvalent immunoglobulin as the second antibody. "

08/01/2007 - "To purify P0 protein from guinea pig's inner ear by preparative SDS-PAGE and to study the possible role it may play in the etiology of autoimmune inner ear disease. "
08/01/2007 - "To purify P0 protein from guinea pig's inner ear by preparative SDS-PAGE and study the possible role it may play in the etiology of autoimmune inner ear disease. "
08/01/2007 - "P0 protein from guinea pigs in ner ear can be successfully purified by preparative SDS-PAGE and an animal model of experimental autoimmune inner ear disease induced by P0 protein was successfully established."
08/01/2007 - "[Animal model of experimental autoimmune inner ear disease induced by P0 protein purified from inner ear]."
08/01/2007 - "P0 protein from guinea pig's inner ear can be successfully purified by preparative SDS-PAGE and an animal model of experimental autoimmune inner ear disease induced by P0 protein is successfully established."

02/01/1996 - "Guinea pig inner ear antigens: extraction and application to the study of human autoimmune inner ear disease."
12/01/2014 - "A number of antigens have been implicated in autoimmune inner ear disease. "
03/01/2010 - "We describe 2 cases of bilateral Ménière disease with features resembling autoimmune inner ear disease in patients who were found to be carriers of human leukocyte antigen (HLA) B27. "
01/01/2009 - "Oral antigen tolerance may be used to treat autoimmune inner ear disease."
05/01/2004 - "Although immune-mediated inner ear disease was reported around 25 years ago, numerous attempts to identify the inner ear antigens have been performed. "

05/01/2007 - "The sole presence of antibodies to myelin P0 may not be used as a marker of inner ear disease of autoimmune origin."
05/01/2004 - "This often leads to a clinical diagnosis of autoimmune inner ear disease, although it is not clear how these antibodies cause inner ear disease. "
09/01/2001 - "We and other groups have previously demonstrated that a 58-kDa protein extracted from guinea pig or bovine inner ear tissue is a target of antibodies in serum samples from some patients with autoimmune inner ear diseases. "
02/01/2001 - "These findings indicate that the sole presence of antibodies to myelin P0 in the sera of guinea pigs or patients suspected of having autoimmune inner ear diseases is unlikely to elicit auditory abnormalities and that additional factors are necessary for the pathogenic development of these disorders."
05/24/1995 - "These results show that antibodies in sera from patients with inner ear disease reacted with at least two polypeptide bands (30 and 58 kDa) of guinea pig inner ear extracts, and the 58 kDa antigenic epitope was not cochlea specific."

11/01/2012 - "A total of 11 control subjects and 85 patients with clinical and audiometric characteristics of IM-SNHL (autoimmune inner ear disease and sudden SNHL combined) treated with corticosteroids were enrolled in the study. "
06/01/2009 - "Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease."
10/01/2004 - "Corticosteroids are standard treatment for a number of inflammatory and immune-mediated inner ear diseases. "
05/01/2009 - "Autoimmune inner ear disease (AIED) is a rare disease that is diagnosed after clinical suspicion and response to corticosteroids. "
01/01/2013 - "Cyclosporine-A could be proposed as a therapeutic option in case of autoimmune inner ear disease allowing the suspension of corticosteroids that, at high dose, expose patients to potentially serious adverse events. "

04/01/2008 - "If the variability in peak concentration and gradient is also present under clinical conditions, this may contribute to the heterogeneity of outcome that is observed after intratympanic application of glucocorticoids for various inner ear diseases."
04/01/2008 - "In recent years, intratympanically applied glucocorticoids are increasingly being used for the treatment of inner ear disease. "
09/01/2006 - "These results emphasis how GR activity modulates hearing sensitivity and its importance for the rationale use of glucocorticoids in inner ear diseases."
03/01/2003 - "Interest in glucocorticoids for topical treatment of inner ear diseases is increasing. "
03/01/2002 - "Although glucocorticoids are widely used to treat inner ear diseases, glucocorticoid concentration has never been determined in the cochlear tissue. "

05/15/2004 - "In the present study, we investigated the potential use of human amniotic epithelial cells, proposed to possess pluripotential properties, as a source of transplantation therapy in inner ear disease. "
01/01/2014 - "Our results demonstrate that, upon transplantation, BMSCs and BMSCs expressing recombinant IL-4 have the ability to remediate the inflammatory injury in autoimmune inner ear diseases."

09/01/1997 - "This study aimed to evaluate the outcome of long-term hearing benefits of plasmapheresis (PMP) in presumed autoimmune inner ear disease (AIED). "
09/01/1997 - "Plasmapheresis in autoimmune inner ear disease: long-term follow-up."
11/01/1989 - "Theoretical and practical implications for plasmapheresis in autoimmune inner ear disease."

08/01/2013 - "Our innovative method using laser microdissection and semi-nested RT-PCR should advance future RNA study of human inner ear diseases."

01/01/1992 - "Recent placebo-controlled clinical double-blind trials failed to confirm any beneficial effects of rheological and vasodilative drugs or hemodilution in treatment of inner ear diseases. "

10/01/2015 - "To succinctly consolidate research and opinion regarding the pathogenesis of autoimmune inner ear disease, in ongoing efforts to elucidate the molecular and intracellular pathways that lead to inner ear damage, which may identify new targets for pharmacotherapy. "
02/01/2009 - "MRI may contribute to our understanding of inner ear diseases and may be a useful addition to intratympanic drug therapy in the management of inner ear diseases. "
03/01/2007 - "It is important for the development of intratympanic drug therapies for inner-ear diseases to investigate how the drugs enter and leave the inner ear."
01/01/2005 - "Round-window anatomical considerations in intratympanic drug therapy for inner-ear diseases."
11/01/2001 - "Autoimmune inner ear disease: steroid and cytotoxic drug therapy."