High expression of CPNE3 predicts adverse prognosis in acute myeloid leukemia.

Abstract

CPNE3, a member of a Ca2+ -dependent phospholipid-binding protein family, was identified as a ligand of ERBB2 and has a more general role in carcinogenesis. Here, we identified the prognostic significance of CPNE3 expression in acute myeloid leukemia (AML) patients based on two datasets. In the first microarray dataset (n = 272), compared to low CPNE3 expression (CPNE3low ), high CPNE3 expression (CPNE3high ) was associated with adverse overall survival (OS, P < 0.001) and event-free survival (EFS, P < 0.001). In the second independent group of AML patients (TCGA dataset, n = 179), CPNE3high was also associated with adverse OS and EFS (OS, P = 0.01; EFS, P = 0.036). Notably, among CPNE3high patients, those received allogenic hematopoietic cell transplantation (HCT) had longer OS and EFS than those with chemotherapy alone (allogeneic HCT, n = 40 vs chemotherapy, n = 46), but treatment modules played an insignificant role in the survival of CPNE3low patients (allogeneic HCT, n = 32 vs chemotherapy, n = 54). These results indicated that CPNE3high is an independent, adverse prognostic factor in AML and might guide treatment decisions towards allogeneic HCT. To understand its inherent mechanisms, we investigated genome-wide gene/microRNA expression signatures and cell signaling pathways associated with CPNE3 expression. In conclusion, CPNE3high is an adverse prognostic biomarker for AML. Its effect may be attributed to the distinctive genome-wide gene/microRNA expression and related cell signaling pathways.

• Authors: Lin Fu, Huaping Fu, Jianlin Qiao, Yifan Pang, Keman Xu, Lei Zhou, Qingyun Wu, Zhenyu Li, Xiaoyan Ke, Kailin Xu, Jinlong Shi
• Journal: Cancer science (Cancer Sci) Vol. 108 Issue 9 Pg. 1850-1857 (Sep 2017) ISSN: 1349-7006 [Electronic] England
• PMID: 28670859 (Publication Type: Journal Article)
• Copyright: © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• Biomarkers, Tumor
• Phosphoproteins
• copine III

Topics

• Adolescent
• Adult
• Biomarkers, Tumor (genetics, metabolism)
• Disease-Free Survival
• Female
• Humans
• Kaplan-Meier Estimate
• Leukemia, Myeloid, Acute (metabolism, mortality, pathology)
• Male
• Middle Aged
• Multivariate Analysis
• Phosphoproteins (genetics, metabolism)
• Prognosis
• Transcriptome
• Young Adult