Therapeutic efficacy of human umbilical cord mesenchymal stem cells transplantation against renal ischemia/reperfusion injury in rats.
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| Abstract | BACKGROUND:
Acute kidney injury (AKI) is a common clinical problem raising the urgent needs to develop new strategies for treatment. The present study investigated the therapeutic potential of human umbilical cord - mesenchymal stem cells (HUC-MSCs) transplantation against renal ischemia/reperfusion injury (IRI) in rats. METHODS: Twenty four male Wistar rats were assigned into two main groups, sham group (control group) and I/R group. I/R group was injected in the tail vein with either phosphate buffer saline (PBS) or HUC-MSCs. RESULTS: The HUC-MSCs improved kidney injury induced by I/R as demonstrated by enhancement of the kidney function via decreasing serum levels of creatinine, urea and uric acid. The therapeutic efficacy of HUC-MSCs were found to be mediated through anti-oxidant activity as indicated by significant reduction in total malondialdehyde (MDA) and significant increment in the levels of reduced glutathione (GSH), catalase (CAT) and glutathione-S-transferase (GST). CONCLUSION: The present work suggests that HUC-MSCs may be an effective therapeutic agent against renal IRI. The recorded data showed improvement of renal functions and urine albumin in HUC-MSCs than IRI group with positive antioxidant efficacy of HUC-MSCs through scavenging free radicals and supporting the antioxidant enzymes.
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| Authors | Sohair R Fahmy, Amel M Soliman, Mervat El Ansary, Samah Abd Elhamid, Heba Mohsen |
| Journal | Tissue & cell (Tissue Cell) Vol. 49 Issue 3 Pg. 369-375 (Jun 2017) ISSN: 1532-3072 [Electronic] Scotland |
| PMID | 28476205 (Publication Type: Journal Article) |
| Copyright | Copyright © 2017 Elsevier Ltd. All rights reserved. |
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