Background.
Inflammation and
pain are closely related to humans' and animals' health.
Resveratrol (RSV) is a natural compound with various biological activities. The current study is aimed to evaluate the
analgesic and anti-inflammatory activities of RSV in vivo. Materials and Methods. The
analgesic effects were assessed by the
acetic acid-induced writhing and hot plate tests. The anti-inflammatory effects were determined using the
xylene-induced mouse ear oedema, the
acetic acid-induced rat
pleurisy, and
carrageenan-induced rat
synovitis tests, respectively. Results. The
analgesic results showed that RSV could significantly inhibit the number of writhes and improve the time and pain threshold of mice standing on hot plate. The anti-inflammatory results showed that RSV could inhibit the ear oedema of mice. In
acetic acid-induced
pleurisy test, RSV could significantly inhibit the WBC and
pleurisy exudates, could decrease the production of NO, and elevate the activity of SOD in serum. In
carrageenan-induced
synovitis test, RSV could reduce the content of MDA and elevate the T-SOD activity in serum; RSV could inhibit the expressions of TP,
PGE2, NO, and MDA. Conclusion. Shortly, these results indicated that RSV had potent
analgesic and anti-inflammatory activities and could be a potential new drug candidate for the treatment of
inflammation and
pain.