Abstract | Background: Methods: Thirty-six patients with bipolar disorder type I, 39 siblings, and 44 healthy controls were assessed. Serum levels of brain-derived neurotrophic factor, interleukin-6, interleukin-10, tumor necrosis factor-α, C-C motif chemokine 11, C-C motif chemokine 24, and 3-nitrotyrosine were measured, as were the activities of glutathione peroxidase, glutathione reductase, and glutathione S-transferase. Telomere length (T/S ratio) was measured using quantitative polymerase chain reaction. Results: Telomere length was different between the 3 groups (P = .041) with both patients and siblings showing a shorter T/S ratio compared with healthy controls. Patients showed increased levels of interleukin-6 (P = .005) and interleukin-10 (P = .002) compared with controls as well as increased levels of interleukin-6 (p = 0.014) and CCL24 (P = .016) compared with their siblings. C-C motif chemokine 11 levels were increased in siblings compared with controls (P = .015), and a similar tendency was found in patients compared with controls (P = .045). Glutathione peroxidase activity was decreased in patients compared with controls (P = .006) and siblings (P = .025). No differences were found for the other markers. Conclusions: The present results suggest that unaffected siblings may present accelerated aging features. These neurobiological findings may be considered as endophenotypic traits. Further prospective studies are warranted.
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Authors | Mirela Paiva Vasconcelos-Moreno, Gabriel Rodrigo Fries, Carolina Gubert, Bárbara Tietböhl Martins Quadros Dos Santos, Adam Fijtman, Juliana Sartori, Pamela Ferrari, Lucas Kich Grun, Mariana Migliorini Parisi, Fátima Theresinha Costa Rodrigues Guma, Florencia Maria Barbé-Tuana, Flávio Kapczinski, Adriane Ribeiro Rosa, Lakshmi N Yatham, Marcia Kauer-Sant'Anna |
Journal | The international journal of neuropsychopharmacology
(Int J Neuropsychopharmacol)
Vol. 20
Issue 6
Pg. 445-454
(06 01 2017)
ISSN: 1469-5111 [Electronic] England |
PMID | 28339618
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2017. Published by Oxford University Press on behalf of CINP. |
Chemical References |
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Topics |
- Biomarkers
(blood)
- Bipolar Disorder
(drug therapy, metabolism)
- Cellular Senescence
(physiology)
- Cross-Sectional Studies
- Female
- Genetic Predisposition to Disease
- Humans
- Inflammation
(blood)
- Interview, Psychological
- Male
- Middle Aged
- Oxidative Stress
(physiology)
- Siblings
- Telomere
(metabolism)
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