Abstract | BACKGROUND: AIM: METHOD: RESULTS: Girls with Rett syndrome received significantly fewer morphine equivalent opioids postoperatively (M = 0.26 mg·kg-1 ·day-1 , sd = 0.10) compared to girls with adolescent idiopathic scoliosis (M = 0.47mg·kg-1 ·day-1 , sd = 0.13; 95% CI -0.34 to -0.08; P = 0.001) and girls with CP (M = 0.40 mg·kg-1 per day, sd = 0.14; 95% CI -0.27 to -0.02; P = 0.01). Girls with Rett syndrome received significantly fewer opioid patient-controlled analgesic (PCA) bolus doses (given by proxy; M = 42.63, sd = 17.84) compared to girls with adolescent idiopathic scoliosis (M = 98.25, sd = 52.77; 95% CI -96.42 to -14.83; P = 0.01). There was also some evidence indicating girls with Rett syndrome received fewer bolus doses compared to girls with CP (M = 80.88, sd = 38.93; 95% CI -79.05 to 2.55; P = 0.06). On average, girls with Rett syndrome also received smaller total doses of acetaminophen, diazepam, and hydroxyzine. CONCLUSION: This study highlights possible discrepancies in postoperative pain management specific to girls with Rett syndrome and suggests further investigation is warranted to determine best practice for postoperative analgesic management for this vulnerable patient population.
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Authors | Chantel C Barney, Alyssa M Merbler, Kelsey Quest, Breanne J Byiers, George L Wilcox, Scott Schwantes, Samuel A Roiko, Timothy Feyma, Arthur Beisang, Frank J Symons |
Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 27
Issue 3
Pg. 290-299
(Mar 2017)
ISSN: 1460-9592 [Electronic] France |
PMID | 28177174
(Publication Type: Comparative Study, Journal Article)
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Copyright | © 2017 John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Adolescent
- Analgesia, Patient-Controlled
(statistics & numerical data)
- Analgesics, Opioid
(therapeutic use)
- Case-Control Studies
- Developmental Disabilities
(complications)
- Dose-Response Relationship, Drug
- Female
- Humans
- Pain, Postoperative
(drug therapy)
- Rett Syndrome
(complications, surgery)
- Spinal Fusion
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