Spinal Fusion (Spondylosyndesis)

Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)

Also Known As:

Networked: 2150 relevant articles (121 outcomes, 214 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Lenke, Lawrence G: 51 articles (10/2015 - 01/2002)
2.	Bridwell, Keith H: 34 articles (09/2015 - 01/2002)
3.	Betz, Randal R: 18 articles (05/2015 - 10/2003)
4.	Skaggs, David L: 15 articles (09/2015 - 05/2005)
5.	Sponseller, Paul D: 15 articles (06/2015 - 06/2002)
6.	Kim, Yongjung J: 14 articles (12/2015 - 09/2004)
7.	Shah, Suken A: 14 articles (08/2015 - 01/2003)
8.	Newton, Peter O: 14 articles (05/2015 - 01/2006)
9.	Boachie-Adjei, Oheneba: 12 articles (11/2015 - 03/2002)
10.	Samdani, Amer F: 12 articles (11/2014 - 01/2008)

Related Diseases

1.	Scoliosis 03/01/2002 - "The most effective treatment for severe scoliosis is prevention by intervening with early spinal fusion utilizing segmental instrumentation as soon as curves are ascertained and before the onset of severe pulmonary or cardiac dysfunction." 12/03/2013 - "A combination of selective segmental TLIF and posterior spinal fusion is both safe and effective for degenerative scoliosis and excellent long-term clinical outcomes may be achieved. " 12/01/2015 - " children with significant scoliosis and CP classified within GMFCS levels 4 and 5, spinal fusion was associated with an improvement in activity and participation, whereas nonoperative treatment was associated with a small reduction. " 06/01/2012 - "Early onset scoliosis associated with SMA has been successfully treated with growing rod constructs, and posterior spinal fusion can be used in older children. " 07/01/2006 - "Ventral derotation spondylodesis, according to Zielke, achieves good results in operative treatment of idiopathic thoracic scolioses. "
2.	Pain (Aches) 01/01/2006 - "Of the remaining clinical outcome measures (ODI, pain VAS scores, SF-36 scores [mental and physical components], patient satisfaction, and return to work status), only patient satisfaction and scores on the physical component scale of the SF-36 questionnaire were significantly improved in favour of lumbar ADR compared with spinal fusion at 24 months follow-up. " 09/01/2015 - "Our findings suggested that PCEA may be more effective in relieving pain than PCIA for patients undergoing spinal fusion surgeries." 09/01/2009 - "The anterior column support could maintain the sagittal alignment better than the posterior spinal fusion alone in the long-term follow up period while the VAS of pain was improved in the similar results." 05/01/2011 - "Study rationale and context:  Bone graft from the iliac crest has been the gold standard in posterolateral spinal fusion procedures, but is associated with chronic pain at the harvest site. " 01/01/2012 - "The "gold standard" for treatment of intervertebral disc herniations and degenerated discs is still spinal fusion, corresponding to the saying "no disc - no pain". "
3.	Congenital Abnormalities (Deformity) 07/01/2007 - "After surgery, the patient's neurological deficit dramatically improved and spinal fusion was completed without any loss of deformity correction. " 06/15/1995 - "To determine whether the addition of anterior spinal fusion was beneficial in preventing progressive spinal deformity in the very young patient. " 08/15/2009 - "The overall positive effect of surgery depends on the individual effects of spinal fusion (slight reduction in quality of life) and deformity reduction (modest improvement in quality of life)." 04/01/2003 - "Posterior instrumental stabilization and anterior interbody fusion were found to be effective in arresting the disease, correcting kyphotic deformity and maintaining correction until solid spinal fusion." 10/25/2011 - "Halo-pelvic traction plus posterior spondylodesis may be a safe and effective therapy of severe cervicothoracic kyphotic deformity."
4.	Postoperative Pain 04/01/2007 - "We conclude that PCA is an effective and safe method with high satisfaction rate in postoperative pain control in patients who undergo spinal fusion." 06/01/2015 - "The purpose of this study is to quantify the amount of postoperative pain in children with CP undergoing hip reconstruction and spinal fusion. " 09/01/2000 - "The purpose of this study was to examine the effectiveness of patient-controlled analgesia (PCA) in relieving postoperative pain for children and adolescents following spinal fusion. " 06/01/2013 - "Therefore, we focused on the effects of two different standardized fluid regimens (liberal vs. conventional) as well as on two different types of postoperative pain management (thoracic epidural catheter vs. intravenous analgesia) concerning pulmonary function in patients undergoing posterior spinal fusion. " 01/01/2013 - "When matched for age, gender and a history of prior lumbar spinal fusion, postoperative pain scores were on average 3.0 points (95% CI 2.1 - 4.0) lower in MIS vs. OS (rANOVA p < 0.001). "
5.	Low Back Pain (Lumbago) 11/01/2003 - "Intradiscal electrothermal therapy (IDET) is a new treatment option for chronic discogenic low back pain that is minimally invasive and has demonstrated success rates equal to or better than those for spinal fusion at short-term follow-up. " 01/01/2011 - "Spinal fusion is generally considered the "gold standard" in the treatment of low-back pain; however, fusion is also associated with accelerated degeneration of adjacent levels. " 05/01/2008 - "Spinal fusion became what has been termed the "gold standard" for the treatment of mechanical low back pain, yet there was no scientific basis for this. " 02/01/2015 - "Comparison of spinal fusion and nonoperative treatment in patients with chronic low back pain: long-term follow-up of three randomized controlled trials. " 02/01/2015 - "Comparison of spinal fusion and nonoperative treatment in patients with chronic low back pain: long-term follow-up of three randomized controlled trials. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	6-Aminocaproic Acid (6 Aminocaproic Acid)
3.	Aprotinin (Trasylol)
4.	Fibrinogen (Factor I)
5.	recombinant human bone morphogenetic protein-2
6.	celecoxib (Celebrex)
7.	Tranexamic Acid (AMCA)
8.	Bone Morphogenetic Protein 7
9.	Heparin (Liquaemin)
10.	recombinant FVIIa (rFVIIa)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Analgesia
3.	Drug Therapy (Chemotherapy)
4.	Decompression
5.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)