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Acetaminophen (Paracetamol)

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Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.

Also Known As:

Paracetamol; Tylenol; APAP; Panadol; Acetominophen; Acamol; Acephen; N-Acetyl-p-aminophenol; Anacin 3; Acetaco; Algotropyl; Anacin-3; Datril; N-(4-Hydroxyphenyl)acetanilide; p-Acetamidophenol; p-Hydroxyacetanilide; Anacin3; Acetamidophenol; Hydroxyacetanilide; Acetamide, N-(4-hydroxyphenyl)-

Networked: 7157 relevant articles (769 outcomes, 1189 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amides: 231
  - Anilides: 16
    - Acetanilides: 5
      - Acetaminophen: 7157
        propacetamol: 74
        drug combination dextropropoxyphene acetaminophen: 56
        codeine drug combination acetaminophen: 55
        oxycodone-acetaminophen: 52
        SCP 1: 31
        hydrocodone drug combination acetaminophen: 22
        4-(nitroxy)butanoic acid 4-acetylaminophenyl ester: 11
        acetaminophen glucuronide: 10
        Night Nurse: 7
        safapryn: 7
        Ultracet: 7
        Midrin: 6
        acetaminophen sulfate ester: 5
        Nyquil: 5
        3-(glutathion-S-yl)acetaminophen: 3
        acetaminophen cysteine: 3
        Paramax: 3
        phenyltoloxamine drug combination acetominophen: 3
        solpadeine: 3
        Syndol: 3
        caffeine drug combination butalbital acetaminophen: 2
        Ergo-Lonarid: 2
        Migraine-Kranit: 2
        migraleve: 2
        propyphenazone drug combination acetaminophen codeine caffeine: 2
        rhinasal: 2
        SELAPINA: 2
        Stopayne: 2
        caffeine drug combination aspirin acetaminophen: 1
        diacetamate: 1
        diclofenac drug combination carisoprodol caffeine acetaminophen: 1
        L 5409709: 1
        mersyndol: 1
        Mesindol: 1
        Myprodol: 1
        N-hydroxyacetaminophen: 1
        PABRON-GOLD: 1
        panadol soluble: 1
        pholcolix: 1
        propofan: 1
        pseudoephedrine drug combination pholcodine acetaminophen: 1
        Sinutab: 1
        SUR 2647: 1
        2,6-dimethylacetaminophen
        2-(4-acetaminophenoxy)tetrahydropyran
        2-acetylaminophenyl sulfate
        3',5'-dimethylacetaminophen
        3'-hydroxyacetaminophen
        3-(cystein-S-yl)paracetamol
        3-acetylaminophenyl sulfate
        3-hydroxyacetaminophen
        3-methoxyacetaminophen
        3-methylacetaminophen
        3-thiomethylparacetamol
        3-thiomethylparacetamol glucuronide
        4-acetamidophenyl-2-thiophenecarboxylate
        4-acetylaminophenyl sulfate
        4-acryloyloxyacetanilide
        4-caprylamidophenol
        acetaminophen cysteinylglycine
        acetaminophen hemisuccinate
        acetaminophen mercapturate
        acetaminophen-cysteine conjugate
        acetaminophen-mercapturic acid conjugate
        chloracetadol
        efferalgan
        fenalgin
        Fluvaleas
        gamma-glutamylcysteinylacetominophen
        guaifenesin drug combination caffeine acetaminophen
        HIFENAC MR
        Kinuya-chinnetsu
        migraeflux-orange
        N-acetyl-4-benzosemiquinone imine
        N-nitroso-3,5-dinitroacetaminophen
        Neo-fluvaleas
        Paedosed
        paidipyrin
        Pameton
        phenylpropanolamine drug combination dextromethorphan chlorpheniramine acetaminophen
        polyoxyethylene bis(acetaminophen)
        prontalgine
        Propain
        pseudoephedrine drug combination doxylamine succinate dextromethorphan acetaminophen
        Shin Ruru A
        UP 341,01

Experts

1.	Jaeschke, Hartmut: 55 articles (01/2016 - 06/2002)
2.	Lee, William M: 41 articles (01/2016 - 12/2002)
3.	McGill, Mitchell R: 25 articles (12/2015 - 03/2011)
4.	James, Laura P: 23 articles (09/2015 - 05/2002)
5.	Acute Liver Failure Study Group: 20 articles (06/2015 - 03/2003)
6.	Dear, James W: 19 articles (12/2015 - 10/2008)
7.	Moore, R Andrew: 18 articles (09/2014 - 02/2002)
8.	Bernal, William: 17 articles (01/2016 - 02/2002)
9.	Simpson, Kenneth J: 17 articles (12/2015 - 06/2002)
10.	Bateman, D Nicholas: 16 articles (09/2015 - 06/2002)

Related Diseases

1.	Pain (Aches) 12/01/2014 - "In this article, after a brief introduction on the most recent advances on the transition from acute to chronic pain, we have focused on paracetamol, an analgesic drug widely used for over a century for its demonstrated efficacy and tolerability. " 04/01/2013 - "Intravenous paracetamol was found to be the most effective in reducing both blood pressure and heart rate (p < 0.001).The effect on post-operative pain was insignificant. " 02/01/2012 - "Acetaminophen was considered as the most effective treatment for pain by 84 (37.50%) of the patients. " 12/01/2006 - "Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery." 05/01/2010 - "Acetaminophen 1000 mg was significantly more effective than placebo for all but 1 (pain reduced to none at 2 hours) clinically important secondary pain relief outcomes. "
2.	Postoperative Pain 06/01/2011 - "Intravenous APAP is safe, effective for mild-to-moderate postoperative pain, well-tolerated, and has a very favorable side effect profile with no clearly demonstrated clinically significant drug-drug interactions. " 04/01/2010 - "Good evidence supports acetaminophen as an effective and safe reliever of acute postoperative pain." 05/01/2006 - "The analgesic efficacy of a 2 g starting dose of IV paracetamol was superior over the recommended dose of 1g in terms of magnitude and duration of analgesic effect for postoperative pain following third molar surgery, with no significant difference between groups regarding safety." 01/01/2014 - "Our study demonstrated that iv dexketoprofen has superior efficacy for postoperative pain management following day-case operative hysteroscopy when compared with paracetamol and placebo." 01/01/2004 - "A prior Cochrane systematic review concluded that paracetamol is also effective for postoperative pain, but additional trials have since been published. "
3.	Fever (Fevers) 02/01/1986 - "By contrast among 1,1-dioxide derivatives the most effective in preventing pyrogen-induced fever was the ethyl ester (V:c) of benzoic series which appeared to be as active as paracetamol. " 01/01/2013 - "In the intent-to-treat population, paracetamol reduced the incidence of fever ≥38°C, but this reduction was only significant for the infant series, with computed efficacy of 43.0% (95% confidence interval [CI]: 17.4, 61.2), and not significant after the toddler dose (efficacy 15.9%; 95% CI: -19.9, 41.3); results were similar in the per protocol (PP) population. " 12/01/2011 - "The combination of IBU and APAP produces significantly greater fever control than APAP alone, with trends favoring the combination over IBU alone and IBU over APAP alone." 09/01/1997 - "A significantly greater and more rapid reduction of fever was demonstrated with paracetamol than with tepid sponging. " 04/01/2014 - "Recent trials have shown the efficacy of more aggressive approaches to fever reduction, whereas a large randomized trial showed the relative ineffectiveness of acetaminophen alone for fever control. "
4.	Osteoarthritis 06/01/2002 - "Analgesic efficacy of sustained release paracetamol in patients with osteoarthritis of the knee." 12/01/2001 - "Acetaminophen is the safest OTC analgesic and is recommended as first-line treatment for osteoarthritis. " 02/01/2004 - "The interpretation of available evidence on the relative efficacy of nonsteroidal antiinflammatory drugs (NSAID) and acetaminophen in osteoarthritis (OA) has recently been debated. " 08/01/2015 - "While paracetamol can be tried, guidelines recommend non-steroidal anti-inflammatory drugs as first-line treatment for osteoarthritis. " 01/01/2005 - "Data from literature do not support efficacy of paracetamol in treatment of moderate to severe form of osteoarthritis. "
5.	Migraine Disorders (Migraine) 05/01/2010 - "Acetaminophen 1000 mg, a nonprescription drug, is an effective and well-tolerated treatment for episodic and moderate migraine headache. " 12/01/2007 - "Acetaminophen showed poor efficacy for moderate to severe migraine attacks but remains the first choice for children and pregnant women. " 10/01/2005 - "Evaluation of the efficacy of intravenous acetaminophen in the treatment of acute migraine attacks: a double-blind, placebo-controlled parallel group multicenter study." 03/01/2015 - "This trial enrolled patients with unsatisfactory response to nonsteroidal anti-inflammatory or acetaminophen and with migraine lasting longer than 3 h. " 07/01/2014 - "In this study, the effects of acute (1 hour) and chronic (30 days) APAP treatments on cerebral microvessels in a cortical spreading depression (CSD) migraine animal model were investigated. "

Related Drugs and Biologics

1.	Acetaminophen (Paracetamol)
2.	Ibuprofen (Motrin)
3.	Tramadol
4.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
5.	Codeine (Codeine Phosphate)
6.	Aspirin (Acetylsalicylic Acid)
7.	Diclofenac (SR 38)
8.	Analgesics (Analgesic Drugs)
9.	Morphine (MS Contin)
10.	Caffeine (No Doz)

Related Therapies and Procedures

1.	Analgesia
2.	Tonsillectomy
3.	Episiotomy
4.	Ambulatory Surgical Procedures (Outpatient Surgery)
5.	Oral Surgery (Maxillofacial Surgery)