Hydroxyzine (Vistaril)

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.

Also Known As:

Networked: 273 relevant articles (42 outcomes, 40 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Theoharides, T C: 3 articles (10/2005 - 09/2000)
2.	Ghanizadeh, A: 2 articles (06/2013 - 03/2013)
3.	Tajik, Ali: 2 articles (03/2007 - 01/2007)
4.	Shohrati, Majid: 2 articles (03/2007 - 01/2007)
5.	Narumi, Hiroko: 1 article (10/2015)
6.	Inoue, Hirofumi: 1 article (10/2015)
7.	Ohga, Shouichi: 1 article (10/2015)
8.	Koga, Michiaki: 1 article (10/2015)
9.	Matsushige, Takeshi: 1 article (10/2015)
10.	Kajimoto, Madoka: 1 article (10/2015)

Related Diseases

1.	Urticaria (Hives) 07/01/2014 - "Many physicians believe that the most effective way to treat chronic urticaria is to take a nonsedating second-generation H1 -antihistamine in the morning and a sedating first-generation H1 -antihistamine, usually hydroxyzine, at night to enhance sleep. " 08/01/2000 - "It is assumed that hydroxyzine hydrochloride may have caused his urticaria." 08/01/2000 - "We report a case of acute urticaria probably caused by hydroxyzine hydrochloride. " 01/01/1999 - "The impression was probable cholinergic urticaria, for which hydroxyzine was prescribed with fair symptomatic control. " 09/01/1995 - "H1-antagonist (hydroxyzine hydrochloride) in dosage of 10 mg-25 mg thrice a day failed to elicit satisfactory response in 60 out of 170 patients of chronic idiopathic urticaria. "
2.	Pruritus (Itching) 01/01/1984 - "In a subsequent double-blind, crossover, multiple-dose study of 2 weeks' duration, hydroxyzine 0.7 mg/kg three times daily was as effective as hydroxyzine 1.4 mg/kg three times daily in relieving pruritus and promoting resolution of the skin lesions. " 02/01/2013 - "However, the patient's skin condition was exacerbated by the continued use of hydroxyzine to treat her pruritus. " 07/01/1991 - "The results of this investigation demonstrated that hydroxyzine was efficacious in attenuating the incidence of severe pruritus." 01/01/1984 - "After a single oral dose of hydroxyzine, 0.7 mg/kg (mean dose 39.0 +/- 5.4 mg), the mean maximum serum hydroxyzine concentration of 72.5 +/- 11.1 ng/ml occurred at a mean time of 2.1 +/- 0.4 hr. The mean elimination half-life calculated from the terminal linear portion of the serum hydroxyzine concentration vs. time curve was 20.0 +/- 4.1 hr. The mean clearance rate was 9.78 +/- 3.25 ml/min/kg and the mean volume of distribution was 16.0 +/- 3.0 L/kg. The single dose of hydroxyzine suppressed pruritus at the wheal and flare sites from 1 to 36 hr. Maximal suppression of the wheals was 80% and maximal suppression of the flares was 92%. " 02/01/2004 - "A nine-year-old girl presented with supraventricular tachycardia while on clinical doses of hydroxyzine for pruritus. "
3.	Asthma (Bronchial Asthma) 08/01/1978 - "Hypersensitivity to Vistaril in a child with asthma." 01/01/1986 - "The efficacy of 281.7 mg of theophylline monohydrate and a combination of theophylline (240 mg) + hydroxyzine (7.5 mg) were compared in a double-blind, crossover, placebo-controlled study in 15 patients with chronic reversible bronchial asthma. " 04/01/1978 - "The efficacy of 265 mg theophylline (150 mg of the theophylline being slow-release) and the combination of 265 mg theophylline + 7.5 mg hydroxyzine hydrochloride were compared in a double-blind cross-over placebo-controlled study in 12 patients with chronic reversible bronchial asthma. " 04/01/1978 - "The efficacy of oral theophylline and the combination of theophylline + hydroxyzine in chronic bronchial asthma." 12/01/1987 - "Cetirizine's efficacy was compared with that of a placebo and oral hydroxyzine (25 mg) in 10 patients with mild asthma. "
4.	Anxiety Disorders (Anxiety Disorder) 08/01/2003 - "Hydroxyzine may be safe and effective in generalised anxiety disorder." 11/01/1994 - "A multi-centre study was designed to evaluate the efficacy of hydroxyzine in the treatment of patients presenting a generalized anxiety disorder (GAD). " 01/01/1998 - "Recent controlled clinical trials with hydroxyzine have confirmed its efficacy (at a fixed dose of 50 mg) in generalized anxiety disorder--superiority over placebo on all anxiety measures from the first week with early target symptoms which are grouped in a cognitive component of anxiety. " 01/01/1998 - "Recent clinical trials of hydroxyzine in generalized anxiety disorder." 01/01/2010 - "Hydroxyzine for generalised anxiety disorder."
5.	Migraine Disorders (Migraine) 02/01/2013 - "Naproxen and hydroxyzine are commonly used oral rescue therapies for older adults who have migraine or tension headaches. " 09/01/1992 - "Ketorolac is as effective as meperidine and hydroxyzine for the treatment of acute migraine headache." 08/01/1998 - "Double-blind, multicenter trial to compare the efficacy of intramuscular dihydroergotamine plus hydroxyzine versus intramuscular meperidine plus hydroxyzine for the emergency department treatment of acute migraine headache." 09/01/1992 - "Ketorolac versus meperidine and hydroxyzine in the treatment of acute migraine headache: a randomized, prospective, double-blind trial." 02/01/2005 - "The objective was to determine if short-term parenteral dihydroergotamine, dexamethasone and hydroxyzine can terminate chronic migraine and be followed by a continuous respite or conversion to a more benign episodic form without the need for daily oral preventative medication ("carry-over effect"). "

Related Drugs and Biologics

1.	Cetirizine (Zyrtec)
2.	Chlorpheniramine (Chlorphenamine)
3.	Meperidine (Pethidine)
4.	Histamine (Histamine Dihydrochloride)
5.	acrivastine (Semprex)
6.	Hydroxyzine (Vistaril)
7.	Theophylline (Theon)
8.	Terfenadine (Seldane)
9.	Morphine (MS Contin)
10.	Histamine Antagonists (Antihistamines)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Nerve Block (Nerve Blocks)
3.	Local Anesthesia
4.	Aftercare (After-Treatment)
5.	Immunotherapy