Dynamin Functions and Ligands: Classical Mechanisms Behind.
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| Abstract |
Dynamin is a GTPase that plays a vital role in clathrin-dependent endocytosis and other vesicular trafficking processes by acting as a pair of molecular scissors for newly formed vesicles originating from the plasma membrane. Dynamins and related proteins are important components for the cleavage of clathrin-coated vesicles, phagosomes, and mitochondria. These proteins help in organelle division, viral resistance, and mitochondrial fusion/fission. Dysfunction and mutations in dynamin have been implicated in the pathophysiology of various disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Charcot-Marie-Tooth disease, heart failure, schizophrenia, epilepsy, cancer, dominant optic atrophy, osteoporosis, and Down's syndrome. This review is an attempt to illustrate the dynamin-related mechanisms involved in the above-mentioned disorders and to help medicinal chemists to design novel dynamin ligands, which could be useful in the treatment of dynamin-related disorders.
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| Authors | Mahaveer Singh, Hemant R Jadhav, Tanya Bhatt |
| Journal | Molecular pharmacology (Mol Pharmacol) Vol. 91 Issue 2 Pg. 123-134 (Feb 2017) ISSN: 1521-0111 [Electronic] United States |
| PMID | 27879341 (Publication Type: Journal Article, Review) |
| Copyright | Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics. |
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