[Topical corticosteroids as a therapeutic alternative in linear immunoglobulin A bullous dermatosis in childhood: case report].

Abstract

Linear immunoglobulin A dermatosis of childhood is a rare autoimmune disorder. Its etiology remains unknown, although it has been linked to drugs, infections, immunological diseases and lymphoproliferative processes. We report the case of a 6 year old girl who consulted for perioral bullous lesions without other symptoms. Neither treatment with mupirocin nor methylprednisolone therapy achieved remission of cutaneous lesions. Skin biopsy showed a linear immunoglobulin A dermatosis. It was not possible to start treatment with dapsone because of a partial glucose-6-phosphate dehydrogenase deficiency, so topical treatment was maintained with good evolution of lesions. Linear immunoglobulin A dermatosis is a rare disease whose differential diagnosis includes other bullous diseases. Pathology is essential for diagnosis. When treatment with dapsone is not possible, topical corticosteroids may be an alternative, either alone or associated with other treatments.

• Authors: Francisco José Gil Sáenz, Gabriel Durán Urdániz, Marta Fernández Galar, Juan Gimeno Ballester, Ana Herrero Varasa, Rosa Garcés Bordege
• Journal: Archivos argentinos de pediatria (Arch Argent Pediatr) Vol. 114 Issue 6 Pg. e440-e443 (Dec 01 2016) ISSN: 1668-3501 [Electronic] Argentina
• Vernacular Title: Corticoides tópicos como alternativa terapéutica en la dermatosis ampollosa por inmunoglobulina A lineal de la infancia: caso clínico.
• PMID: 27869429 (Publication Type: Case Reports, Journal Article)
• Copyright: Sociedad Argentina de Pediatría.

Chemical References

• Glucocorticoids
• Methylprednisolone

Topics

• Administration, Topical
• Child
• Female
• Glucocorticoids (administration & dosage)
• Humans
• Linear IgA Bullous Dermatosis (drug therapy)
• Methylprednisolone (administration & dosage)