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Mupirocin (Bactroban)

A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.

Also Known As:

Bactroban; BRL-4910A; Mupirocin, 14C-Labeled; Mupirocin, Calcium Salt (2:1); Mupirocin, Calcium Salt (2:1), Dihydrate; Mupirocin, Lithium Salt; Mupirocin, Sodium Salt; Pseudomonic Acid A; 14C-Labeled Mupirocin; Acid, Pseudomonic; BRL 4910A; BRL4910A; Mupirocin, 14C Labeled; Pseudomonic Acid; Nonanoic acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2H-pyran-2-yl)-2-butenyl)oxy)-, (2S-(2alpha(E),3beta,4beta,5alpha(2R*,3R*(1R*,2R*))))-

Networked: 446 relevant articles (93 outcomes, 105 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kluytmans, Jan A J W: 6 articles (10/2011 - 03/2004)
2.	Piraino, Beth: 5 articles (01/2012 - 02/2004)
3.	Johnson, David W: 4 articles (12/2015 - 05/2009)
4.	Cass, Alan: 4 articles (12/2015 - 05/2009)
5.	Clark, Carolyn: 3 articles (12/2015 - 05/2009)
6.	Hawley, Carmel M: 3 articles (12/2015 - 05/2009)
7.	de Zoysa, Janak: 3 articles (12/2015 - 05/2009)
8.	Isbel, Nicole M: 3 articles (12/2015 - 05/2009)
9.	Scaria, Anish: 3 articles (12/2015 - 07/2013)
10.	Beller, Elaine: 3 articles (12/2015 - 05/2009)

Related Diseases

1.	Infection 08/01/1989 - "This study suggests that mupirocin is a safe and effective topical preparation for treating most of our common skin infections." 08/01/1989 - "Mupirocin, a new antibiotic, has proved in vitro and in vivo to be highly effective in the treatment of MRSA infections. " 05/01/1988 - "Mupirocin ointment, a new topical antibiotic, has proved in vitro and in vivo to be highly effective in the treatment of MRSA infections. " 07/01/1995 - "Mupirocin (2% ointment) has also proven effective for topical treatment of these infections. " 11/01/1986 - "Mupirocin 2% ointment administered 2 or 3 times daily has shown excellent efficacy in both primary and secondary superficial skin infections, usually with at least 80% of patients being clinically cured or markedly improved, and over 90% eradication of the bacterial pathogen involved. "
2.	Impetigo 07/01/1989 - "Mupirocin is a new, topical antibiotic effective for the treatment of impetigo. " 05/01/1990 - "Randomized, multicenter, double-blind, vehicle-controlled clinical trials have shown that mupirocin is safe and effective for the treatment of impetigo." 08/01/1989 - "These results show topical mupirocin to be a safe and effective alternative to oral antibiotic therapy in the treatment of impetigo." 12/01/1988 - "Thus, mupirocin appears to be safe and effective in treating impetigo in children. " 12/01/1986 - "Initial studies comparing mupirocin to inactive vehicle in the treatment of impetigo indicate an overall 92 percent pathogen eradication rate with active drug and 58 percent eradication rate with vehicle. "
3.	Peritonitis 10/01/2005 - "Our study, although retrospective, has demonstrated that the topical use of mupirocin was associated with a significant reduction in ESI and peritonitis and, unexpectedly, with findings of fewer incidences of Pseudomonas peritonitis. " 08/01/2005 - "Our study, although limited by its retrospective nature, demonstrated that topical mupirocin was associated with a significant reduction in ESI and peritonitis with unexpected findings of lower Pseudomonas peritonitis. " 09/01/2005 - "Local application of mupirocin led to a significant reduction in the incidence density per patient-month of both ESI and peritonitis compared to controls (0.15 vs 0.37 and 0.37 vs 0.67, p = 0.01 for both). " 04/01/2014 - "The rate of gram-positive peritonitis without mupirocin and the risk of gram-positive peritonitis with mupirocin were influential factors. " 09/01/2012 - "In particular, mupirocin did not reduce Staphylococcus aureus peritonitis rates. "
4.	Wound Infection (Wound Infections) 04/01/2010 - "Prophylactic intranasal mupirocin is safe, inexpensive and effective in reducing the overall sternal wound infection after open-heart surgery. " 02/01/2008 - "Topical mupirocin application was effective against crush wound infections inoculated with S. " 10/01/1985 - "The efficacy of topically-applied mupirocin was evaluated against an experimental surgical staphylococcal wound infection in the guinea-pig. " 07/01/2007 - "The purpose of this study was to investigate the mupirocin resistance in MRSA strains isolated from wound infections of in- and out-patients of two distinct hospitals located in Ankara and Istanbul. " 05/01/2001 - "This study was designed to determine whether decreasing nasal bacterial colonization by applying Mupirocin (MPN) intranasally decreases sternal wound infections. "
5.	Wounds and Injuries (Trauma) 08/01/1989 - "Mupirocin eliminated MRSA in all 59 wounds treated, with the maximum therapeutic response seen within 4 days. " 07/01/2014 - "This study was conducted to analyze the resistance pattern of MRSA to mupirocin among the patients admitted following trauma to an apex trauma care center of India and to compare the efficacy between two methods of antimicrobial sensitivity testing. " 07/01/2014 - "Resistance pattern of mupirocin in methicillin-resistant Staphylococcus aureus in trauma patients and comparison between disc diffusion and E-test for better detection of resistance in low resource countries." 05/01/2009 - "370 subjects will be randomized 1:1 to receive either daily topical exit-site application of Medihoney Antibacterial Wound Gel (all patients) or nasal application of mupirocin if staphylococcal nasal carriage is demonstrated. " 09/01/2008 - "aureus in their wound was 0.48 (95% CI: 0.24-0.97) in the mupirocin period and 0.55 (95% CI: 0.28-1.1) during the C2 period. "

Related Drugs and Biologics

1.	Mupirocin (Bactroban)
2.	Vancomycin
3.	Rifampin (Rifampicin)
4.	Erythromycin (Erycette)
5.	Fusidic Acid (Fucithalmic)
6.	Gentamicins (Gentamicin)
7.	Methicillin (Metin)
8.	Erythromycin Ethylsuccinate (E-Mycin E)
9.	Chlorhexidine
10.	Cephalexin (Cefalexin)

Related Therapies and Procedures

1.	Catheters
2.	Peritoneal Dialysis
3.	Transplants (Transplant)
4.	Renal Dialysis (Hemodialysis)
5.	Topical Administration