Abstract | PURPOSE:
Ketamine-induced cystitis (KC) among chronic ketamine young abusers has increased dramatically and it has brought attention for Urologists. The underlying pathophysiological mechanism(s) of KC is still unclear. Therefore, the purpose of this study is to elucidate the possible pathophysiological mechanism(s) of KC through proteomic techniques. EXPERIMENTAL DESIGN: Bladder tissues are obtained from seven patients with KC, seven patients with interstitial cystitis/ bladder pain syndrome, and five control subjects who underwent video-urodynamic study followed by augmentation enterocystoplasty to increase bladder capacity. 2DE/MS/MS-based approach, functional classifications, and network analyses are used for proteomic and bioinformatics analyses and protein validation is carried out by Western blot analysis. RESULTS: CONCLUSIONS AND CLINICAL RELEVANCE:
|
Authors | Hsueh-Hui Yang, Wei-Jun Zhai, Hann-Chorng Kuo |
Journal | Proteomics. Clinical applications
(Proteomics Clin Appl)
Vol. 11
Issue 3-4
(03 2017)
ISSN: 1862-8354 [Electronic] Germany |
PMID | 27863071
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Actins
- Cytoskeletal Proteins
- Ketamine
|
Topics |
- Actins
(metabolism)
- Adult
- Cystitis
(chemically induced, metabolism)
- Cytoskeletal Proteins
(metabolism)
- Female
- Humans
- Ketamine
(adverse effects)
- Male
- Middle Aged
- Pilot Projects
- Prospective Studies
- Proteomics
|