Cystitis

Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.

Also Known As:

Networked: 2795 relevant articles (213 outcomes, 271 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection)
2.	Inflammation
3.	Prostatitis
4.	Hemorrhage
5.	Pyelonephritis

Experts

1.	Vizzard, Margaret A: 28 articles (01/2015 - 01/2002)
2.	Yoshimura, Naoki: 16 articles (11/2015 - 05/2002)
3.	Chancellor, Michael B: 16 articles (10/2015 - 05/2002)
4.	Hooton, Thomas M: 13 articles (11/2014 - 06/2003)
5.	Matsumoto, Tetsuro: 13 articles (06/2014 - 08/2004)
6.	Tyagi, Pradeep: 11 articles (11/2015 - 05/2004)
7.	Qiao, Li-Ya: 11 articles (05/2015 - 12/2002)
8.	Wang, Zun-Yi: 11 articles (04/2015 - 01/2006)
9.	Bjorling, Dale E: 11 articles (04/2015 - 01/2006)
10.	Hirsch, Hans H: 10 articles (01/2015 - 08/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cystitis:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2016 - "This study investigated the effects of the long-term dietary fish oil supplementation or the acute administration of the omega-3 fatty acid docosahexaenoic acid (DHA) in the mouse hemorrhagic cystitis (HC) induced by the anticancer drug cyclophosphamide (CYP). " 04/01/2015 - "The current study provides strong evidence for a protective role of PEA as well as an alteration in bladder levels of PEA and of some of its targets in cyclophosphamide induced cystitis." 02/01/2014 - "The purpose of the study is to explore the function of P2X3 and NK1 receptors antagonists on cyclophosphamide (CYP)-induced cystitis in rats. " 01/01/2012 - "We performed an intraperitoneal (ip) injection of cyclophosphamide to induce cystitis in rats, which causes their detrusors to overact, to provide a valuable disease model for discussing OAB pathogenesis and to study effective curing methods. " 01/01/2010 - "To our knowledge we report the first study of alterations in O-GlcNAc mediated glycosylation activity in bladders with cyclophosphamide induced cystitis. "
2.	Mesna (Coenzyme M)FDA LinkGeneric 06/01/1999 - "Mesna offers good protection against CP cystitis for only certain posologies. " 11/01/1991 - "Although previous reports had suggested that the sulfhydryl-containing compound mesna might be superior to forced diuresis in preventing hemorrhagic cystitis, there were concerns about the effect of mesna on engraftment in these studies. " 11/01/2015 - "Continuous IV infusion of MESNA can prevent hemorrhagic cystitis in HSCT and retain MESNA concentration in urine." 09/01/2015 - "We observed similar incidence rate for hemorrhagic cystitis in both patient groups concomitantly treated with or without mesna [9/583 (1.5%) vs 8/425 (1.8%) respectively, p = 0.08]. " 09/01/2015 - "All of the following information was obtained: the cumulative CYC dose, route of CYC administration, duration of therapy, concomitant mesna usage, and hemorrhagic cystitis. "
3.	OxygenIBA 10/01/2015 - "To analyze the efficacy of hyperbaric oxygen for the treatment of radiation-induced hemorrhagic cystitis and to identify factors associated with successful treatment. " 02/01/1999 - "Radiation induced hemorrhagic cystitis that does not respond to standard regimens can be successfully treated with hyperbaric oxygen. " 09/01/1998 - "With over 80 cases reported of radiation-induced cystitis treated successfully with hyperbaric oxygen, attention is now turning to the treatment of chemotherapeutic agent-induced cystitis. " 12/01/2012 - "Hyperbaric oxygen (HBO) has been demonstrated to be an effective treatment for radiation-induced hemorrhagic cystitis not responding to conventional management. " 05/01/2014 - "Early primary use of hyperbaric oxygen to treat radiation-induced grade IV cystitis is an effective and safe treatment option."
4.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric 01/01/2015 - "An 82-year-old woman presented to the emergency department with altered mental status thought to be due to complicated cystitis and was treated with TMP-SMX 160 mg/800 mg orally twice daily for 7 days. " 05/01/2014 - "Short- and long-term cure rates of short-duration trimethoprim-sulfamethoxazole treatment in female dogs with uncomplicated bacterial cystitis." 04/01/2013 - "Cotrimoxazole (after susceptibility testing) is efficient in case of S. saprophyticus's cystitis. " 01/01/2013 - "The proportion of TMP-SMX-resistant E coli causing acute cystitis in women in Canada remains below 20% nationally, but may exceed this level in premenopausal women. " 01/01/2013 - "Trimethoprim-sulfamethoxazole (TMP-SMX) has been a traditional first-line antibiotic treatment for acute cystitis; however, guidelines do not recommend TMP-SMX in regions where Escherichia coli resistance exceeds 20%. "
5.	IfosfamideFDA LinkGeneric 02/01/2012 - "In IL-4-treated animals, the severity of hemorrhagic cystitis was significantly milder than in animals treated with ifosfamide only, an effect that was reverted with serum anti-IL-4. " 10/01/2009 - "IPC inhibited VE (38.8%) and VP (54%) in ifosfamide-induced hemorrhagic cystitis. " 01/01/2007 - "Ifosfamide (IFS) is an antineoplastic alkylating agent whose major side effect is hemorrhagic cystitis (HC). " 06/01/1995 - "The adverse effect most frequently associated with ifosfamide is hemorrhagic cystitis. " 11/01/1993 - "Ifosfamide (IF) is an alkylating cytostatic drug with urotoxic (hemorrhagic cystitis) and nephrotoxic side effects. "
6.	Ciprofloxacin (Cipro)FDA LinkGeneric 06/01/2015 - "The purpose of this study was to investigate the effect of ciprofloxacin treatment on quality of life and symptom improvement in patients with simple cystitis. " 01/01/1997 - "The efficacy of ciprofloxacin was studied in the treatment of 50 women (the average age of 41.6 years) with acute noncomplicated cystitis. " 06/01/2011 - "An increasing tendency of resistance to ciprofloxacin (24.8%) has been observed compared with the similar studies in 2006 (23.4%) and 2002 (15.2%) from patients with uncomplicated cystitis. " 01/01/2011 - "[Efficacy and safety of cefixim and ciprofloxacin in acute cystitis (a multicenter randomized trial)]." 01/01/2012 - "The clinical and microbiological effectiveness of Cystostop Rapid was comparable to that of ciprofloxacin, providing a two-fold more rapid improvement of cystitis symptoms, at a mean time to improvement of 24 hours (p < 0.02) versus 46 hours for ciprofloxacin. "
7.	FosfomycinFDA Link 12/01/2015 - "Fosfomycin is recommended as first-line treatment for acute uncomplicated cystitis in women. " 12/01/2015 - "Of particular interest is fosfomycin, which is unrelated to other antibiotic classes and may take a more prominent role in treating MDRO cystitis." 08/01/2012 - "Fosfomycin is a wide-spectrum antibiotic that is used clinically to treat acute cystitis in the United States. " 09/01/2010 - "In the era of high drug resistance rates, reported even among community-acquired uropathogens, fosfomycin may provide a valuable alternative option for the treatment of cystitis in non-pregnant and pregnant women and in elderly and paediatric patients." 04/01/2010 - "In USA, the Food and Drug Administration (FDA) has approved fosfomycin only for the treatment of patients with uncomplicated cystitis. "
8.	Amoxicillin (Wymox)FDA LinkGeneric 04/01/2005 - "Amoxicillin was found to be effective for the treatment of community-acquired cystitis, thus suggesting that the development of bacterial resistance does not represent a limit to its use. " 07/01/1985 - "It was concluded that A-CA was effective in reducing the bacterial count and reducing the histopathological changes in the bladder and urethra in an experimental model of acute bacterial cystitis in cats infected with an E coli demonstrating in vitro resistance to amoxycillin." 01/01/1976 - "1. Amoxicillin was remarkably effective in 13 cases of acute cystitis, in terms of effect according to dose and bacterial species. " 04/01/2005 - "In our study we have evaluated the effectiveness of amoxicillin, a narrow-spectrum, inexpensive and non toxic drug, against non-complicated acute cystitis in 34 patients, and compared the results with the antibiotic therapy previously employed by the physicians of the Health Care Unit of Paola (CS), Italy. " 07/01/2001 - "We conclude that single-dose amoxicillin is inadequate therapy for uncomplicated cystitis of childhood. "
9.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/1980 - "The most recent data suggest that much lower doses of some beta-lactam antibiotics than have been contemplated hitherto may be effective in the treatment of uncomplicated cystitis." 06/01/2015 - "Quality of life and changes in symptom relief in patients with acute uncomplicated cystitis treated with antibiotics: a prospective, open-label, multicenter, observational study." 06/01/2015 - "coli(a): 'simple cystitis but recurrent with susceptibility to standard antibiotics', in our study." 02/01/2009 - "Antibiotics versus placebo in the treatment of women with uncomplicated cystitis: a meta-analysis of randomized controlled trials." 05/01/2005 - "The study population included women aged 18-75 years without risk factors for complicated UTI who were treated empirically with antibiotics for a diagnosis of acute cystitis or UTI. "
10.	Ofloxacin (Levofloxacin)FDA LinkGeneric 03/01/2006 - "[Efficacy of levofloxacin in the treatment of recurrent cystitis in women]." 01/01/2000 - "[Efficacy of single-dose therapy with levofloxacin for acute cystitis: comparison to three-day therapy]." 02/01/1992 - "[Clinical efficacy of levofloxacin (LVFX) single-dose therapy in female acute uncomplicated cystitis]." 09/01/2015 - "coli isolated from acute uncomplicated cystitis patients, 11.1% were levofloxacin-resistant strains. " 04/01/2012 - "We describe the case of a 75-year-old woman who was prescribed a 15-day course of levofloxacin (500 mg twice a day) for hemorrhagic cystitis. "

Therapies and Procedures

1.	Intravesical Administration 10/01/2014 - "Intravesical instillation of GTE attenuated the inflammatory response to UPEC-SR71-induced bacterial cystitis and is a novel approach to the treatment of bacterial cystitis. " 10/01/2014 - "Intravesical instillation of GTE attenuated the inflammatory response to UPEC-SR71-induced bacterial cystitis in this rat model. " 10/01/2014 - "In vivo effects of intravesical instillation of GTE on bacterial cystitis was analysed using a rat model of bacterial cystitis. " 08/01/2012 - "Intravesical instillation of EPI preserves UPII expression and attenuates the toxic responses in the bladder in CYP-induced rat cystitis." 09/01/2011 - "In eight rats, chemical cystitis was induced by intravesical instillation of HCl. "
2.	Drug Therapy (Chemotherapy) 01/01/2015 - "Our experience indicate that HBOT is a safe and effective therapeutic option for treatment-resistant radiogenic and chemotherapy-induced haemorrhagic cystitis. " 12/01/1989 - "Single dose chemotherapy with an adequate antibiotic is considered a useful treatment for female acute cystitis." 02/01/1992 - "[A clinical study on postantibiotic effect (PAE) and its application to chemotherapy for complicated cystitis with an automatic simulator of urinary drug concentration]." 04/01/2014 - "This may provide a new treatment strategy for chemotherapy associated cystitis." 05/01/2013 - "Although chemical cystitis is the most common side effect and is usually self-limiting, significant toxicity can occur with intravesical chemotherapy. "
3.	Radiotherapy 08/01/1999 - "Twenty patients with grade 3 radiation cystitis after radiotherapy were enrolled into this study. " 05/01/2015 - "The treatment of pelvic malignancies with radiotherapy can develop severe sequelae, especially radiation-induced hemorrhagic cystitis. " 01/01/2015 - "Twenty-three consecutive patients with symptomatic cystitis after external radiotherapy for PCa were enrolled. " 07/01/2014 - "Hemorrhagic radiation cystitis is an example of a typical radiotherapy-induced adverse event. " 05/01/2014 - "Chronic radiation cystitis (CRC) is a serious complication that can arise in patients with pelvic malignancies treated with radiotherapy. "
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 09/01/2014 - "The aim of this study was to evaluate the usefulness of ultrasonography in the diagnosis of hemorrhagic cystitis following bone marrow transplantation in children. " 08/01/2015 - "Patients who received bone marrow transplantation (BMT) had significantly longer duration of hemorrhagic cystitis than those who did not receive BMT (p < 0.05). " 03/01/2015 - "Łasecki Ultrasonography in the diagnosis of hemorrhagic cystitis - a complication of bone marrow transplantation in pediatric oncology patients." 02/01/2015 - "Hemorrhagic cystitis (HC) is a troublesome and potentially life-threatening complication of bone marrow transplantation (BMT). " 09/01/2014 - "Ultrasonography in the diagnosis of hemorrhagic cystitis - a complication of bone marrow transplantation in pediatric oncology patients."
5.	Hyperbaric Oxygenation 12/01/2008 - "Although there are some conservative treatments such as hyperbaric oxygen therapy for radiation-induced hemorrhagic cystitis, in emergency circumstances selective embolization of the internal iliac artery may be beneficial with fewer side effects. " 10/01/2015 - "Hyperbaric oxygen therapy for refractory radiation-induced hemorrhagic cystitis." 06/01/2014 - "Hyperbaric oxygen therapy for hemorrhagic cystitis." 02/01/2013 - "Hyperbaric oxygen therapy for hemorrhagic radiation cystitis." 02/01/2013 - "Hyperbaric oxygen therapy for hemorrhagic radiation cystitis."