EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent.

Abstract

Wound healing is a complex multifactorial process that relies on coordinated signaling molecules to succeed. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair; however, precise control over its application is necessary to reduce the side effects and achieve desired therapeutic benefits. Moreover, the extensive oxidative stress during the wound healing process generally inhibits repair of the injured tissues. Topical applications of antioxidants like curcumin (Cur) could protect tissues from oxidative damage and significantly improve tissue remodeling. To achieve much accelerated wound healing effects, we designed a novel dual drug co-loaded in situ gel-forming nanoparticle/hydrogel system (EGF-Cur-NP/H) which acted not only as a supportive matrix for the regenerative tissue, but also as a sustained drug depot for EGF and Cur. In the established excisional full-thickness wound model, EGF-Cur-NP/H treatment significantly enhanced wound closure through increasing granulation tissue formation, collagen deposition, and angiogenesis, relative to normal saline, nanoparticle/hydrogel (NP/H), Cur-NP/H, and EGF-NP/H treated groups. In conclusion, this study provides a biocompatible in situ gel-forming system for efficient topical application of EGF and Cur in the landscape of tissue repair.

• Authors: Xiaoling Li, Xianlong Ye, Jianying Qi, Rangrang Fan, Xiang Gao, Yunzhou Wu, Liangxue Zhou, Aiping Tong, Gang Guo
• Journal: International journal of nanomedicine (Int J Nanomedicine) Vol. 11 Pg. 3993-4009 ( 2016) ISSN: 1178-2013 [Electronic] New Zealand
• PMID: 27574428 (Publication Type: Journal Article)

Chemical References

• Platelet Endothelial Cell Adhesion Molecule-1
• Polyesters
• Transforming Growth Factor beta1
• Hydrogel, Polyethylene Glycol Dimethacrylate
• poly(lactide)
• Epidermal Growth Factor
• Curcumin

Topics

• 3T3 Cells
• Animals
• Cell Death (drug effects)
• Cell Proliferation (drug effects)
• Curcumin (pharmacology)
• Drug Liberation
• Epidermal Growth Factor (pharmacology)
• HEK293 Cells
• Humans
• Hydrogel, Polyethylene Glycol Dimethacrylate (chemistry)
• Mice
• Nanoparticles (chemistry)
• Platelet Endothelial Cell Adhesion Molecule-1 (metabolism)
• Polyesters (chemistry)
• Regeneration (drug effects)
• Skin (drug effects)
• Transforming Growth Factor beta1 (metabolism)
• Wound Healing (drug effects)