Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSION: These results indicate that tideglusib shows neuroprotection against hypoxic-ischemic brain injury in neonatal mice. GENERAL SIGNIFICANCE:
Tideglusib is a potential compound for the prevention or treatment of hypoxic-ischemic brain injury in neonates.
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Authors | Haitao Wang, Sammen Huang, Kuipo Yan, Xiaoyan Fang, Ahmed Abussaud, Ana Martinez, Hong-Shuo Sun, Zhong-Ping Feng |
Journal | Biochimica et biophysica acta
(Biochim Biophys Acta)
Vol. 1860
Issue 10
Pg. 2076-85
(10 2016)
ISSN: 0006-3002 [Print] Netherlands |
PMID | 27378458
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier B.V. All rights reserved. |
Chemical References |
- Enzyme Inhibitors
- Neuroprotective Agents
- Thiadiazoles
- Glycogen Synthase Kinase 3 beta
- Gsk3b protein, mouse
- Proto-Oncogene Proteins c-akt
- Caspase 3
- tideglusib
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Topics |
- Animals
- Animals, Newborn
- Brain Injuries
(drug therapy)
- Caspase 3
(biosynthesis)
- Disease Models, Animal
- Enzyme Inhibitors
(administration & dosage)
- Gene Expression Regulation
(drug effects)
- Glycogen Synthase Kinase 3 beta
(antagonists & inhibitors, metabolism)
- Humans
- Hypoxia-Ischemia, Brain
(drug therapy, pathology)
- Mice
- Neuroprotective Agents
(administration & dosage)
- Phosphorylation
(drug effects)
- Proto-Oncogene Proteins c-akt
(genetics)
- Signal Transduction
(drug effects)
- Thiadiazoles
(administration & dosage)
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