Abstract | INTRODUCTION: African American (AA) women diagnosed with breast cancer are more likely to have aggressive subtypes. Investigating differentially expressed genes between patient populations may help explain racial health disparities. Resistin, one such gene, is linked to inflammation, obesity, and breast cancer risk. Previous studies indicated that resistin expression is higher in serum and tissue of AA breast cancer patients compared to Caucasian American (CA) patients. However, resistin expression levels have not been compared between AA and CA patients in a stage- and subtype-specific context. Breast cancer prognosis and treatments vary by subtype. This work investigates differential resistin gene expression in human breast cancer tissues of specific stages, receptor subtypes, and menopause statuses in AA and CA women. METHODS: Differential gene expression analysis was performed using human breast cancer gene expression data from The Cancer Genome Atlas. We performed inter-race resistin gene expression level comparisons looking at receptor status and stage-specific data between AA and CA samples. DESeq was run to test for differentially expressed resistin values. RESULTS: CONCLUSION:
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Authors | Karin A Vallega, NingNing Liu, Jennifer S Myers, Kaixian Yu, Qing-Xiang Amy Sang |
Journal | PloS one
(PLoS One)
Vol. 11
Issue 6
Pg. e0157741
( 2016)
ISSN: 1932-6203 [Electronic] United States |
PMID | 27314854
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Receptors, Estrogen
- Receptors, Progesterone
- Resistin
- Receptor, ErbB-2
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Topics |
- Adult
- Black or African American
(genetics)
- Biomarkers, Tumor
(biosynthesis, genetics)
- Breast Neoplasms
(genetics, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Middle Aged
- Neoplasm Staging
- Receptor, ErbB-2
- Receptors, Estrogen
(genetics)
- Receptors, Progesterone
(genetics)
- Resistin
(biosynthesis, genetics)
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