Abstract | BACKGROUND: RESULTS: Twelve days post infection lack of serglycin proteoglycans caused significantly increased enteropathy. The serglycin-deficient mice showed significantly increased intestinal worm burden, reduced recruitment of mast cells to the intestinal crypts, decreased levels of the mast cell proteases MCPT5 and MCPT6 in intestinal tissue, decreased serum levels of TNF-α, IL-1β, IL-10 and IL-13, increased levels of IL-4 and total IgE in serum, and increased intestinal levels of the neutrophil markers myeloperoxidase and elastase, as compared to wild type mice. At five weeks post infection, increased larvae burden and inflammation were seen in the muscle tissue of the serglycin-deficient mice. CONCLUSIONS: Our results demonstrate that the serglycin-deficient mice were more susceptible to T. spiralis infection and displayed an unbalanced immune response compared to wild type mice. These findings point to an essential regulatory role of serglycin proteoglycans in immunity.
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Authors | Ananya Roy, Osama Sawesi, Ulrika Pettersson, Anders Dagälv, Lena Kjellén, Anna Lundén, Magnus Åbrink |
Journal | BMC immunology
(BMC Immunol)
Vol. 17
Issue 1
Pg. 15
(06 08 2016)
ISSN: 1471-2172 [Electronic] England |
PMID | 27267469
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Proteoglycans
- Tpsb2 protein, mouse
- Vesicular Transport Proteins
- serglycin
- Cma1 protein, mouse
- Chymases
- Tryptases
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Topics |
- Animals
- Cell Movement
- Chymases
(metabolism)
- Cytokines
(metabolism)
- Immunity, Mucosal
- Intestinal Diseases, Parasitic
(immunology)
- Intestines
(immunology, parasitology)
- Mast Cells
(immunology, parasitology)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Neutrophils
(immunology)
- Proteoglycans
(genetics, metabolism)
- Th1-Th2 Balance
- Trichinella spiralis
(immunology)
- Trichinellosis
(immunology)
- Tryptases
(metabolism)
- Vesicular Transport Proteins
(genetics, metabolism)
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