Abstract | BACKGROUND: METHODS: RESULTS: Administration of nefopam before and after SNL induced significant antiallodynic effects (P < .01, respectively), which were significantly reduced by glibenclamide (P < .01). Pinacidil improved the antiallodynic effects of nefopam (P < .01); however, apamin and charybdotoxin had little effects on the antiallodynic properties of nefopam. CONCLUSIONS:
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Authors | Won Uk Koh, Jin Woo Shin, Ji-Yeon Bang, Sae Gyeol Kim, Jun-Gol Song |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 123
Issue 3
Pg. 762-70
(09 2016)
ISSN: 1526-7598 [Electronic] United States |
PMID | 27224932
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- KATP Channels
- Potassium Channel Blockers
- Nefopam
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Topics |
- Analgesics, Non-Narcotic
(pharmacology, therapeutic use)
- Animals
- Disease Models, Animal
- Hyperalgesia
(drug therapy, pathology)
- KATP Channels
(agonists, antagonists & inhibitors, physiology)
- Male
- Nefopam
(pharmacology, therapeutic use)
- Neuralgia
(drug therapy, pathology)
- Potassium Channel Blockers
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Treatment Outcome
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