Abstract | BACKGROUND: METHODS: RESULTS: We found that cholesterol changes cancer cell morphology with the appearance of protrusions together to the down expression of β-actin gene and reduction of β-actin protein. The lipid influences SUP-T1 cell aggressiveness since stimulates DNA and RNA synthesis for cell proliferation and increases raf1 and E-cadherin, molecules involved in invasion and migration of cancer cells. Cholesterol does not change GRX2 expression but it overexpresses SOD1, SOD2, CCS, PRDX1, GSR, GSS, CAT and PNKP. We suggest that cholesterol reaches the nucleus and increases the nuclear lipid microdomains known to act as platform for chromatin anchoring and gene expression. CONCLUSION:
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Authors | Michela Codini, Samuela Cataldi, Andrea Lazzarini, Anna Tasegian, Maria Rachele Ceccarini, Alessandro Floridi, Remo Lazzarini, Francesco Saverio Ambesi-Impiombato, Francesco Curcio, Tommaso Beccari, Elisabetta Albi |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 15
Pg. 4
(Jan 12 2016)
ISSN: 1476-511X [Electronic] England |
PMID | 26754536
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cadherins
- RNA
- DNA
- Cholesterol
- raf Kinases
- Sphingomyelin Phosphodiesterase
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Topics |
- Cadherins
(metabolism)
- Cell Line, Tumor
- Cell Nucleus
(metabolism)
- Cholesterol
(blood)
- DNA
(biosynthesis)
- Hematologic Neoplasms
(blood, pathology)
- Humans
- Membrane Microdomains
(metabolism)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(blood, pathology)
- RNA
(biosynthesis)
- Sphingomyelin Phosphodiesterase
(metabolism)
- raf Kinases
(metabolism)
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