Abstract |
Gliomas are the most common malignant primary brain tumors, and new clinical biomarkers and therapeutic targets are imminently required. MicroRNAs ( miRNAs) are a novel class of small non-coding RNAs (∼22nt) involved in the regulation of various biological processes. Here, by using real-time polymerase chain reaction, miRNA-132 was found to be significantly deregulated in glioma tissues. Based on the prediction of the target genes of miR-132, we hypothesized that there is a significant association between miR-132 and matrix metalloproteinase ( MMP) 16 (MT3-MMP), a protein of the MMP family. We showed that the up-expression of miR-132 inhibited cell migration and invasion in the human glioma cell lines A172, SHG44, and U87. Furthermore, the overexpression of miR-132 reduced the expression of MMP16 in A172, SHG44, and U87 cells. Taken together, our study suggested that miR-132 affects glioma cell migration and invasion by MMP16 and implicates miR-132 as a metastasis-inhibiting miRNA in gliomas.
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Authors | Hangzhou Wang, Xue-Tao Li, Chun Wu, Zhi-Wu Wu, Yan-Yan Li, Tian-Quan Yang, Gui-Lin Chen, Xue-Shun Xie, Yu-Lun Huang, Zi-Wei Du, You-Xin Zhou |
Journal | OncoTargets and therapy
(Onco Targets Ther)
Vol. 8
Pg. 3211-8
( 2015)
ISSN: 1178-6930 [Print] New Zealand |
PMID | 26604788
(Publication Type: Journal Article, Retracted Publication)
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