Abstract | BACKGROUND: Perfluoroalkyl acids are synthetic compounds widely used in industrial and commercial applications. Laboratory studies suggest that these persistent and bioaccumulative chemicals produce oxidant stress and damage glomerular endothelial cells, raising concern regarding the impact of these compounds on renal function. METHODS: RESULTS: While adjusting for demographics, cotinine, prehypertension, insulin resistance, body mass index, and hypercholesterolemia, adolescents in the highest PFOA and PFOS quartile had a lower eGFR, 6.84 mL/min/1.73 m(2) (95% CI: 2.19 to 11.48) and 9.69 mL/min/1.73 m(2) (95 % CI: -4.59 to 14.78), respectively, compared to the lowest quartile. Highest PFOA and PFOS quartiles were also associated with 0.21 mg/dL (95% CI: 0.056 to 0.37) and 0.19 mg/dL (95% CI: 0.032 to 0.34) increases in uric acid, respectively. CONCLUSIONS: PFAAs are associated with a reduction in kidney function and increased uric acid levels in otherwise healthy adolescents. Reverse causation and residual confounding could explain the results. Our study results confirm and amplify previous findings, though longitudinal studies examining prenatal and childhood biomarkers in relationship with robust measures of childhood renal function are needed.
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Authors | Anglina Kataria, Howard Trachtman, Laura Malaga-Dieguez, Leonardo Trasande |
Journal | Environmental health : a global access science source
(Environ Health)
Vol. 14
Pg. 89
(Nov 21 2015)
ISSN: 1476-069X [Electronic] England |
PMID | 26590127
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Alkanesulfonic Acids
- Biomarkers
- Caprylates
- Environmental Pollutants
- Fatty Acids
- Fluorocarbons
- Sulfonic Acids
- Uric Acid
- perfluorohexanesulfonic acid
- perfluoro-n-nonanoic acid
- perfluorooctanoic acid
- perfluorooctane sulfonic acid
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Topics |
- Adolescent
- Alkanesulfonic Acids
(blood, toxicity)
- Biomarkers
(blood)
- Caprylates
(blood, toxicity)
- Child
- Cross-Sectional Studies
- Environmental Exposure
(adverse effects, analysis)
- Environmental Pollutants
(blood, toxicity)
- Fatty Acids
- Female
- Fluorocarbons
(blood, toxicity)
- Glomerular Filtration Rate
(drug effects)
- Humans
- Male
- Nutrition Surveys
- Sulfonic Acids
(blood, toxicity)
- United States
- Uric Acid
(blood)
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