Abstract | BACKGROUND: METHODS: RESULTS: A significant difference between the mean serum TIMP-1 and MMP-9 levels and the alanine transaminase activity was found among the groups. Compared with the I/RG group a significant difference in the mean tissue MMP-9, MPO, and TBARS levels in addition to the PAB and FRAP was found between the CG and IG groups. The level of MMP-9 also demonstrated a strong, positive, and valid correlation with the TBA-RS levels. A significant morphological change was observed in both the IG and the I/RG groups. The degree of intestinal injury was more severe in the I/R group and was characterized by either villous denudation or villous loss. CONCLUSIONS: These results suggest that MMP-9, TIMP-1, MPO, and oxidative stress may be important in the intestinal injury development that is induced by acute mesenteric I/R in a rat model. MMP-9 overexpression may increase the extent of intestinal villous loss, particularly when MMP-9 is upregulated by the TBARS present in the intestinal injury.
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Authors | A Kocael, B B Inal, G Guntas, C Kelten, H Inal, H I Topac, P Kocael, O Simsek, G Karaca, Z Salihoglu, H Uzun |
Journal | Human & experimental toxicology
(Hum Exp Toxicol)
Vol. 35
Issue 8
Pg. 851-60
(Aug 2016)
ISSN: 1477-0903 [Electronic] England |
PMID | 26429927
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2015. |
Chemical References |
- TIMP1 protein, rat
- Tissue Inhibitor of Metalloproteinase-1
- Peroxidase
- Matrix Metalloproteinase 9
- Mmp9 protein, rat
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Topics |
- Animals
- Intestinal Mucosa
(blood supply, metabolism, pathology)
- Lipid Peroxidation
(physiology)
- Male
- Matrix Metalloproteinase 9
(blood, metabolism)
- Mesenteric Arteries
(enzymology, metabolism, pathology, physiopathology)
- Oxidative Stress
(physiology)
- Peroxidase
(blood, metabolism)
- Rats, Sprague-Dawley
- Reperfusion Injury
(blood, enzymology, pathology, physiopathology)
- Splanchnic Circulation
(physiology)
- Tissue Inhibitor of Metalloproteinase-1
(blood, metabolism)
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