Abstract |
Patients with familial hypercholesterolemia (FH) are at increased risk of premature cardiovascular disease. We compared factors associated with the presence of carotid plaques and carotid intima-media thickness (cIMT), markers of subclinical atherosclerosis, in 241 patients with FH (98, 40.7% men; mean age 41 ± 18.4 years). Patients with FH having carotid plaques (36.5%) had mean age, apolipoprotein ( apo) B, glucose, apoA1, systolic blood pressure (SBP) and diastolic BP, waist/hip ratio (WHR), and body mass index higher than patients without plaques. Logistic regression revealed that apoB (odds ratio [OR] per 1 unit change 1.03,P= .005), high-density lipoprotein cholesterol (HDL-C; OR per 1 standard deviation [SD] change 0.59,P= .015), and non-HDL-C (OR per 1SD change 1.53,P= .04) were significantly associated with the presence of plaques. The cIMT correlated with obesity parameters, BP, apoB, glucose, high-sensitivity C-reactive protein, creatinine, γ- glutamyl transpeptidase, and alanine transaminase (P< .001). Regression analysis revealed that cIMT was significantly associated with apoB, SBP, and WHR. These results confirm the role of apoB-containing lipoproteins and low HDL-C with the presence of carotid plaques and apoB, BP, and WHR with cIMT.
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Authors | Małgorzata Waluś-Miarka, D Czarnecka, W Wojciechowska, M Kloch-Badełek, M Kapusta, M Sanak, M Wójcik, M T Małecki, J Starzyk, B Idzior-Waluś |
Journal | Angiology
(Angiology)
Vol. 67
Issue 5
Pg. 471-7
(May 2016)
ISSN: 1940-1574 [Electronic] United States |
PMID | 26198473
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2015. |
Chemical References |
- Apolipoproteins B
- Cholesterol, HDL
- Lipoproteins, HDL
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Topics |
- Adult
- Aged
- Apolipoproteins B
(blood)
- Atherosclerosis
(blood, complications)
- Blood Pressure
(physiology)
- Carotid Intima-Media Thickness
- Cholesterol, HDL
(blood)
- Female
- Humans
- Hyperlipoproteinemia Type II
(complications, diagnosis, metabolism)
- Lipoproteins, HDL
(metabolism)
- Male
- Middle Aged
- Risk Factors
- Young Adult
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