Bullous pemphigoid after allogeneic hematopoietic stem cell transplantation.

Abstract

Bullous pemphigoid (BP) is an autoimmune skin disorder characterized by subepidermal blisters due to deposit of autoantibody against dermal basement membrane protein. It has been reported that BP can occur after allogeneic hematopoietic stem cell transplantation (HSCT). We describe a patient with BP having autoantibody against BP180 after unrelated-donor HSCT against T lymphoblastic leukemia. The patient was treated with steroid leading to complete resolution of BP, but T lymphoblastic leukemia progressed rapidly after steroid hormone treatment. Given that immunosuppressant may reduce graft-versus-tumor effect, immunomodulatory agents such as nicotinamide and tetracycline, erythromycin, and immunoglobulin may be appropriate as soon as typical blister lesions are seen after HSCT.

• Authors: Keisuke Kato, Kazutoshi Koike, Chie Kobayashi, Shigeruko Iijima, Takashi Hashimoto, Masahiro Tsuchida
• Journal: Pediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 57 Issue 3 Pg. 480-3 (Jun 2015) ISSN: 1442-200X [Electronic] Australia
• PMID: 26113316 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 Japan Pediatric Society.

Topics

• Adolescent
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Leukemia, T-Cell (therapy)
• Male
• Pemphigoid, Bullous (diagnosis, etiology)
• Skin (pathology)