Abstract | CONTEXT: OBJECTIVE: The objective of the study was to determine whether adolescents and young adults with classical CAH have more VAT and sc adipose tissue (SAT) than matched controls and whether VAT and SAT are associated with biomarkers of metabolic syndrome, inflammation, and hyperandrogenism in CAH. DESIGN/SETTING: This was a cross-sectional study at a tertiary center. PARTICIPANTS: CAH subjects (n = 28; 15.6 ± 3.2 y; 15 females) were matched for age, sex, ethnicity, and body mass index to healthy controls (n = 28; 16.7 ± 2.3 y; 15 females). MAIN OUTCOME MEASURES: VAT and SAT, using computed tomography imaging and serum biomarkers associated with CVD risk, were measured. Data are reported as mean ± SD. RESULTS: CONCLUSIONS: CAH adolescents and young adults have increased abdominal adiposity, with a higher proportion of proinflammatory VAT than SAT. An improved understanding of the mechanism of obesity in CAH may lead to targeted prevention and therapeutics in this high-risk population.
|
Authors | Mimi S Kim, Anna Ryabets-Lienhard, Anh Dao-Tran, Steven D Mittelman, Vicente Gilsanz, Sheree M Schrager, Mitchell E Geffner |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 100
Issue 8
Pg. E1153-9
(Aug 2015)
ISSN: 1945-7197 [Electronic] United States |
PMID | 26062016
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Topics |
- Abdominal Fat
(diagnostic imaging, pathology)
- Adiposity
- Adolescent
- Adrenal Hyperplasia, Congenital
(complications, epidemiology, pathology)
- Adult
- Child
- Cross-Sectional Studies
- Female
- Humans
- Intra-Abdominal Fat
(diagnostic imaging, pathology)
- Male
- Obesity, Abdominal
(complications, epidemiology, pathology)
- Pediatric Obesity
(complications, epidemiology, pathology)
- Subcutaneous Fat
(diagnostic imaging, pathology)
- Tomography, X-Ray Computed
- Young Adult
|