[Advance in studies of Panax notoginseng saponins on pharmacological mechanism of nervous system disease].

Abstract

The pharmacological mechaisms of Panax notoginseng saponins on nervous system diseases (Alzheimer's disease, Parkinson's disease, ischermic cerebral apoplexy and depressive disorder) , including panax notoginseng saponins, protoparaxotriol saponins, panasadiol saponins, ginsenoside Rg1, ginsenoside Rb1, ginsenoside Re and notoginsenoside R1 were summarized to analyze the study hotspots and potential advantages (such as estrogen-like effect) of notoginsenoside's pharmacological actions, provide reference for further pharmacological studies and new ideas for clinical treatment of nervous system diseases and drug studies and development.

• Authors: Ping Su, Lei Wang, Shi-Jing Du, Wen-Feng Xin, Wen-Sheng Zhang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 39 Issue 23 Pg. 4516-21 (Dec 2014) ISSN: 1001-5302 [Print] China
• PMID: 25911793 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Drugs, Chinese Herbal
• Saponins

Topics

• Animals
• Drugs, Chinese Herbal (administration & dosage)
• Gene Expression (drug effects)
• Humans
• Nervous System Diseases (drug therapy, genetics, metabolism)
• Panax notoginseng (chemistry)
• Saponins (administration & dosage)