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notoginsenoside R1

Also Known As:

notoginsenoside R 1; sanchinoside R1; beta-D-glucopyranoside, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-

Networked: 93 relevant articles (16 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Ginsenosides: 1010
        notoginsenoside R1: 93
Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - Ginsenosides: 1010
      - notoginsenoside R1: 93

Experts

1.	Sun, Guibo: 8 articles (01/2021 - 02/2016)
2.	Sun, Xiaobo: 8 articles (01/2021 - 02/2016)
3.	Wang, Lei: 4 articles (04/2022 - 12/2014)
4.	Fan, Jing-Yu: 4 articles (01/2021 - 01/2008)
5.	Han, Jing-Yan: 4 articles (01/2021 - 01/2008)
6.	Liu, Yu-Ying: 4 articles (01/2021 - 01/2008)
7.	Meng, Xiangbao: 4 articles (01/2021 - 02/2018)
8.	Zhang, Xuelian: 4 articles (02/2020 - 01/2018)
9.	Wang, Yan: 4 articles (01/2019 - 01/2016)
10.	Li, Quan: 3 articles (01/2021 - 01/2014)

Related Diseases

1.	Reperfusion Injury 01/01/2014 - "Protective effects of Notoginsenoside R1 on intestinal ischemia-reperfusion injury in rats." 01/01/2023 - "Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury." 03/21/2020 - "Notoginsenoside R1 Suppresses Inflammatory Signaling and Rescues Renal Ischemia-Reperfusion Injury in Experimental Rats." 11/01/2019 - "Notoginsenoside R1 exhibited potent characteristics of neuroprotective, anti-inflammatory, anti-apoptosis and anti-ischemia-reperfusion injury properties etc. The cytotoxic effects of notoginsenoside R1 were dependent on different types of cell lines. " 01/01/2019 - "Notoginsenoside R1 for Organs Ischemia/Reperfusion Injury: A Preclinical Systematic Review."
2.	Brain Ischemia (Cerebral Ischemia) 12/01/2017 - "Protective effects of notoginsenoside R1 on cerebral ischemia-reperfusion injury in rats." 05/01/2022 - "Notoginsenoside R1 ameliorates mitochondrial dysfunction to circumvent neuronal energy failure in acute phase of focal cerebral ischemia." 12/01/2017 - "The objective of this study was to investigate the protective effect of notoginsenoside R1 (NGR1) on cerebral ischemia-reperfusion injury (CIRI) in rats, and its molecular mechanism, to provide new insights into the diagnosis and treatment of CIRI. " 09/01/2021 - "Notoginsenoside R1 treatment attenuates BBB permeability, cerebral infarction volume and neurological impairments in rats with acute cerebral ischemia. " 01/01/2021 - "Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway."
3.	Diabetic Nephropathies (Diabetic Nephropathy) 10/01/2016 - "Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the PI3K/Akt signaling pathway." 01/10/2019 - "Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression." 01/01/2019 - "Notoginsenoside R1 (NG-R1) is a major component of Panax notoginseng, which has been used clinically for the treatment of diabetic nephropathy for centuries in China. " 12/01/2019 - "Notoginsenoside R1 (NGR1) is a major bioactive ingredient of Radix notoginseng that has promise in treating several diabetes-related diseases, like diabetic nephropathy and diabetic cardiomyopathy. " 06/01/2018 - "Notoginsenoside R1 (NGR1) is a predominant phytoestrogen extracted from Panax notoginseng that has recently been reported to play important roles in the treatment of cardiac dysfunction, diabetic kidney disease, and acute liver failure. "
4.	Acute Lung Injury 01/01/2022 - "Notoginsenoside R1 (NG-R1), the extract and the main ingredient of Panax notoginseng, has anti-inflammatory effects and can be used in treating acute lung injury (ALI). " 06/01/2021 - "To clarify the mechanism of notoginsenoside R1 in the treatment of septic acute lung injury (ALI) based on network pharmacological analysis, and to verify it in the model of septic ALI in rats. " 01/01/2022 - "Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis." 06/01/2021 - "Protective effects of notoginsenoside R1 on acute lung injury in rats with sepsis."
5.	Diabetic Retinopathy (Retinopathy, Diabetic) 02/17/2020 - "Correction: Zhou, P., et al. Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy. " 01/01/2019 - "Notoginsenoside R1 Ameliorates Diabetic Retinopathy through PINK1-Dependent Activation of Mitophagy."

Related Drugs and Biologics

1.	Inflammasomes
2.	Saponins
3.	ginsenoside Rg1
4.	ginsenoside Rb1
5.	Xylose (D-Xylose)
6.	Apolipoproteins E (ApoE)
7.	Aconitine
8.	ginsenoside Re
9.	shikonin
10.	Apoptosis Regulatory Proteins

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)