Abstract | OBJECTIVE: We undertook a non-targeted lipidomics analysis of post-mortem cerebrospinal fluid (CSF), frontal cortex grey matter, and subjacent white matter to define potential biomarkers that distinguish cognitively intact subjects from those with incipient or established dementia. Our objective was to increase our understanding of the role of brain lipids in pathophysiology of aging and age-related cognitive impairment. METHODS: Levels of 650 individual lipids, across 26 lipid subclasses, were measured utilising a high-resolution mass spectrometric analysis platform. RESULTS: CONCLUSION: The parallel changes in grey matter MAGs and DAGs in the MCI and OD groups suggest that these two cohorts may have a similar underlying pathophysiology; consistent with this, MCI subjects were more similar in age to OD than to YD subjects. While PlsEtn and phosphatidylethanolamine were decreased in the YD and OD groups they were unaltered in the MCI group indicating that alterations in plasmalogen synthesis are unlikely to represent an initiating event in the transition from MCI to dementia.
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Authors | Paul L Wood, Brooke L Barnette, Jeffrey A Kaye, Joseph F Quinn, Randall L Woltjer |
Journal | Acta neuropsychiatrica
(Acta Neuropsychiatr)
Vol. 27
Issue 5
Pg. 270-8
(Oct 2015)
ISSN: 1601-5215 [Electronic] England |
PMID | 25858158
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Diglycerides
- Monoglycerides
- Plasmalogens
- phosphatidal ethanolamines
- Docosahexaenoic Acids
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Topics |
- Age Factors
- Aged
- Aged, 80 and over
- Alzheimer Disease
(cerebrospinal fluid, metabolism, pathology)
- Biomarkers
(cerebrospinal fluid, metabolism)
- Brain
(metabolism)
- Cognitive Dysfunction
(cerebrospinal fluid, metabolism, pathology)
- Dementia
(metabolism, pathology)
- Diagnosis
- Diglycerides
(cerebrospinal fluid, metabolism)
- Docosahexaenoic Acids
(cerebrospinal fluid, metabolism)
- Female
- Frontal Lobe
(metabolism)
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Monoglycerides
(cerebrospinal fluid, metabolism)
- Neuropsychological Tests
- Plasmalogens
(cerebrospinal fluid, metabolism)
- White Matter
(metabolism)
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