Plasmalogens

01/01/2022 - "The oral ingestion of scallop-derived plasmalogen (sPlas) significantly improved cognitive function in Alzheimer's disease (AD) patients. "
07/31/2023 - "Plasmalogen Improves Memory Function by Regulating Neurogenesis in a Mouse Model of Alzheimer's Diseases."
01/01/2023 - "Decreased plasmalogen levels have been associated with neurological diseases like Alzheimer's disease. "
01/01/2022 - "Clinical and Pathological Benefits of Scallop-Derived Plasmalogen in a Novel Mouse Model of Alzheimer's Disease with Chronic Cerebral Hypoperfusion."
10/20/2021 - "Plasmalogens (Pls) are bioactive substances enriched in the brain with a regulatory effect on Alzheimer's disease (AD), while their metabolomic influence accompanying AD and the underlying mechanisms remain unclear. "

01/01/2021 - "Reduced plasmalogen levels have been observed in metabolic diseases; hence, increasing their levels might be beneficial in ameliorating these conditions. "
01/01/2021 - "This study was designed to evaluate the impact of SLO supplementation on endogenous plasmalogen levels in individuals with features of metabolic disease. "
11/01/2021 - "Plasmalogens (Pls) levels are reported to be altered in several neurological and metabolic diseases. "
01/01/2020 - "Deep understanding of plasmalogens biosynthesis will provide the bases for the use of plasmalogens and their precursors as potential therapeutic regimens for age-related degenerative and metabolic diseases."
01/01/2020 - "In animals, impaired biosynthesis and regulation of plasmalogens may lead to certain neurological and metabolic diseases. "

01/01/2020 - "These data extend previous studies by showing an association of decreased plasmalogen indices with AD, mild cognitive impairment (MCI), cognition, and CSF tau. "
01/01/2010 - "The use of both ADAS-Cog and serum plasmalogen data may be a more accurate way of predicting cognitive decline in AD patients, and may be used to decrease the risk of including patients with no cognitive decline in the placebo arm of a drug trial."
01/01/2023 - "The objective of the study was to assess the effectiveness of a unique extract of plasmalogen from scallops for older adults with concerns either about memory and cognition or some form of actual memory loss or cognitive dysfunction. "
01/01/2019 - "Our result suggests that brain plasmalogen is one of the key molecules to control behavior and that its injection using liposome is a potential therapeutic approach for cognitive impairment."
03/01/2017 - "Efficacy and Blood Plasmalogen Changes by Oral Administration of Plasmalogen in Patients with Mild Alzheimer's Disease and Mild Cognitive Impairment: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial."

05/01/2014 - "Serum plasmalogens (Pls) (1-O-alk-1'-enyl-2-acyl glycerophospholipids) are of particular interest for studies on metabolic disorders associated with oxidative stress and chronic inflammation. "
01/01/2023 - "Here, we proposed a pathobiological model for post-COVID-19 and ME/CFS based on their common inflammation and dysfunctional glial reactivity, and highlighted the emerging implications of plasmalogen deficiency in the underlying mechanisms. "
11/01/2022 - "However, the molecular mechanisms underlying the roles of plasmalogens in inflammation have remained largely elusive. "
01/01/2021 - "However, it has been shown that in inflammatory processes, plasmalogens could trigger either an anti- or pro-inflammation response. "
01/01/2021 - "Currently, there is a lack of full understanding of the molecular mechanisms governing the association of plasmalogens with inflammation. "

11/17/2023 - "Plasmalogens (Pls) are considered to play a potential role in the treatment of neurodegenerative diseases. "
10/15/2022 - "Decreased plasma levels of plasmalogens in neurodegenerative diseases have been watched with interest. "
05/01/2022 - "Therefore, reduced levels of plasmalogens have been suggested to be associated with neurodegenerative diseases such as Alzheimer's disease. "
01/01/2021 - "To investigate the underlying mechanisms of decreased plasmalogens (Pls) levels in neurodegenerative diseases, here the effects of seafood-derived Pls on undifferentiated and differentiated human SH-SY5Y neuroblastoma cells exposed to amyloid-β1-42 was analyzed. "
04/24/2023 - "Plasmalogens (Pls), a special group of phospholipids, are effective in ameliorating neurodegenerative disease. "