Abstract | BACKGOUND:
Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β- tubulin, bcl-2 and ERCC 1, which are well-known biomarkers to predict the chemotherapy response, according to HPV status in OPC patients. METHODS: RESULTS: Seventy-four patients were enrolled for this study and all patients received induction chemotherapy with docetaxel, 5-FU and cisplatin. After induction chemotherapy, complete response (CR) was shown in 22 patients (30%) and partial response (PR) in 46 patients (62%). HPV + was detected in 21 patients (28%), while 35 patients (47%) showed p16+ expression by IHC analysis. p16 positive patients showed better overall response, PFS and OS than p16 negative patients. p53 and class III beta-tubulin expression were significantly higher in HPV- and p16- than HPV + and p16+ patients. Conversely, bcl-2 expression was greater in HPV + or p16+ than HPV- or p16- patients. ERCC1 expression did not differ significantly according to HPV status. In multivariate analyses, early T stage (p = 0.036) and good PS (PS 0) (p = 0.029) showed a better 3Y-PFS rate, and low p53 expression (p = 0.012) and complete response after induction chemotherapy (p = 0.026) were highly associated with 3Y-OS rate. Low expression of p53 and p16 positive patients showed significantly prolonged OS than others (p = 0.010). CONCLUSION: P53, class III beta-tubulin and bcl-2 were differently expressed in OPC according to HPV status and present study suggested the underlying mechanism of better response to chemotherapy in case of HPV OPC than non-HPV OPC. Among these biomarkers, p53 is the strongest prognostic marker in OPC and p53 in addition to p16 support the rationale to study of de-escalation strategy for OPC.
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Authors | Min-Jee Kim, Myung-Seo Ki, Karham Kim, Hyun-Jeong Shim, Jun-Eul Hwang, Woo-Kyun Bae, Ik-Joo Chung, Dong-Hoon Lee, Joon-Kyoo Lee, Tae-Mi Yoon, Sang-Chul Lim, Woong-Ki Chung, Jae-Uk Jeong, Hoi-Soon Lim, Yoo-Duk Choi, Sang-Hee Cho |
Journal | BMC cancer
(BMC Cancer)
Vol. 14
Pg. 824
(Nov 07 2014)
ISSN: 1471-2407 [Electronic] England |
PMID | 25380690
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- DNA-Binding Proteins
- Proto-Oncogene Proteins c-bcl-2
- Tubulin
- Tumor Suppressor Protein p53
- ERCC1 protein, human
- Endonucleases
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biomarkers, Tumor
(genetics, metabolism)
- Combined Modality Therapy
- DNA-Binding Proteins
(genetics, metabolism)
- Endonucleases
(genetics, metabolism)
- Female
- Humans
- Male
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
- Oropharyngeal Neoplasms
(drug therapy, metabolism, mortality, pathology, virology)
- Papillomaviridae
(genetics)
- Papillomavirus Infections
(virology)
- Proto-Oncogene Proteins c-bcl-2
(genetics, metabolism)
- Risk Factors
- Treatment Outcome
- Tubulin
(genetics, metabolism)
- Tumor Suppressor Protein p53
(genetics, metabolism)
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