Abstract | PURPOSE: PROCEDURES: Therefore, in an observational study blood, visceral adipose tissue and liver tissue were obtained from 93 severely obese patients with a mean age of 43 years and mean BMI of 52 kg/m2 at the time of weight loss surgery. In a subset of patients a follow-up blood sample was obtained 6 weeks after surgery to assess acute effects of weight loss. In addition to routine parameters of liver injury, serum samples were analyzed for leptin, adiponectin, free fatty acids (FFAs), and several apolipoproteins. MAIN FINDINGS: The diameter of visceral adipocytes correlated to liver injury, serum markers of inflammation and serum adipokine levels. Liver injury assessed by serology (ALT, AST) and histology ( NAFLD activity score, NAS) was independent of the BMI. However, serum levels of triglycerides and Apolipoprotein CIII (ApoCIII) were associated with NAS. Serum levels and composition of FFAs, especially long chain FFAs, also correlated with NAS. Analysis of serum samples six weeks after surgery revealed beneficial changes in serum triglycerides, levels of ApoCIII and several FFAs. CONCLUSIONS: In severely obese patients beneficial effects on liver injury can been observed as early as six weeks after bariatric surgery. These effects may be explained by the observed changes in adipose tissue and lipid metabolism. Collectively, these findings underline the importance of the link between adipose tissue and the liver.
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Authors | Alexander Wree, Martin Schlattjan, Lars P Bechmann, Thierry Claudel, Jan-Peter Sowa, Tatjana Stojakovic, Hubert Scharnagl, Harald Köfeler, Hideo A Baba, Guido Gerken, Ariel E Feldstein, Michael Trauner, Ali Canbay |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 63
Issue 12
Pg. 1542-52
(Dec 2014)
ISSN: 1532-8600 [Electronic] United States |
PMID | 25267016
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
- Adiponectin
- Apolipoproteins
- Fatty Acids, Nonesterified
- Leptin
- C-Reactive Protein
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Topics |
- Adipocytes
(physiology)
- Adiponectin
(metabolism)
- Adult
- Apolipoproteins
(blood)
- Bariatric Surgery
- C-Reactive Protein
(metabolism)
- Cell Size
- Cohort Studies
- Disease Progression
- Fatty Acids, Nonesterified
(blood)
- Female
- Humans
- Leptin
(metabolism)
- Male
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(enzymology, pathology)
- Obesity
(metabolism, pathology, surgery)
- Severity of Illness Index
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