Abstract | INTRODUCTION: Although several studies have shown that the presence of acellular mucin pools in surgical specimens with rectal carcinomas examined after preoperative chemoradiotherapy indicated complete response to therapy, the proper meaning of these pools has yet to be elucidated. The aims of this study were to analyze the immunoprofile of acellular mucin pools and to review the relevant literature. METHODS: RESULTS: Acellular mucin pools were present in all the cases, independently by their preoperative histological aspect. In remnant tumors (n=20), they were present at the invasion front and were marked by CEA. In cases without remnant tumor cells (n=10), they also displayed CEA positivity. In 2 of the 10 cases, isolated tumor cells were identified after multilevel sectioning of paraffin-embedded blocks. CONCLUSIONS: The presence of acellular mucin pools in surgical specimens of rectal cancers cannot be interpreted as an indicator of complete response to radiotherapy if at least 10 multilevel sections are performed in at least three tumor blocks per case, and CEA negativity is not proved.
|
Authors | Simona Gurzu, Tivadar Bara, Tivadar Bara Jr, Zoltan Kadar, Calin Molnar, Attila Kovecsi, Ioan Jung |
Journal | Cancer biotherapy & radiopharmaceuticals
(Cancer Biother Radiopharm)
Vol. 29
Issue 7
Pg. 295-7
(Sep 2014)
ISSN: 1557-8852 [Electronic] United States |
PMID | 25203146
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Carcinoembryonic Antigen
- Mucins
- Keratins
|
Topics |
- Aged
- Carcinoembryonic Antigen
(metabolism)
- Carcinoma
(drug therapy, metabolism)
- Chemoradiotherapy
(methods)
- Female
- Humans
- Keratins
(metabolism)
- Male
- Middle Aged
- Mucins
(metabolism)
- Preoperative Period
- Rectal Neoplasms
(drug therapy, metabolism, radiotherapy)
|