Abstract | BACKGROUND: METHODS: Thirty-two adult male New Zealand white rabbits were randomly divided into four groups of eight rabbits in each group: group 1 (control); group 2 ( subarachnoid hemorrhage); group 3 ( subarachnoid hemorrhage + vehicle); and group 4 ( subarachnoid hemorrhage + testosterone). Testosterone (15 mg/kg, intraperitoneally) was administered 5 min after the intracisternal blood injection and continued for 72 h once per day in the same dose for group 4. Animals were killed 72 h after subarachnoid hemorrhage. Basilar artery cross-sectional areas, arterial wall thicknesses, and hippocampal degeneration scores were evaluated in all groups. RESULTS: CONCLUSIONS:
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Authors | Bora Gürer, Erhan Turkoglu, Hayri Kertmen, Ergun Karavelioglu, Ata Türker Arikok, Zeki Sekerci |
Journal | Acta neurochirurgica
(Acta Neurochir (Wien))
Vol. 156
Issue 11
Pg. 2111-20; discussion 2120
(Nov 2014)
ISSN: 0942-0940 [Electronic] Austria |
PMID | 25194970
(Publication Type: Journal Article)
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Chemical References |
- Neuroprotective Agents
- Vasodilator Agents
- Testosterone
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Topics |
- Animals
- Basilar Artery
(drug effects, pathology)
- Disease Models, Animal
- Hippocampus
(drug effects, pathology)
- Injections, Intraperitoneal
- Male
- Neuroprotective Agents
(pharmacology)
- Rabbits
- Subarachnoid Hemorrhage
(complications)
- Testosterone
(pharmacology)
- Vasoconstriction
(drug effects)
- Vasodilator Agents
(pharmacology)
- Vasospasm, Intracranial
(etiology)
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