Abstract | OBJECTIVE: METHODS:
POMC neuron-specific CN-FoxO1/ Sirt1 double-KI (DKI) mice were analyzed. RESULTS: The obese phenotype of CN-FoxO1 KI mice was rescued in male DKI mice. Reduced O2 consumption, increased adiposity, and fewer POMC neurons observed in CN-FoxO1 mice were rescued in male DKI mice without affecting food intake and locomotor activity. Sirt1 overexpression decreased FoxO1 acetylation and protein levels without affecting its nuclear localization in mouse embryonic fibroblasts and hypothalamic N41 cells. CONCLUSIONS:
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Authors | Vina Yanti Susanti, Tsutomu Sasaki, Hiromi Yokota-Hashimoto, Sho Matsui, Yong-Soo Lee, Osamu Kikuchi, Mayumi Shimpuku, Hye-Jin Kim, Masaki Kobayashi, Tadahiro Kitamura |
Journal | Obesity (Silver Spring, Md.)
(Obesity (Silver Spring))
Vol. 22
Issue 10
Pg. 2115-9
(Oct 2014)
ISSN: 1930-739X [Electronic] United States |
PMID | 25044690
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 The Authors Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS). |
Chemical References |
- Forkhead Transcription Factors
- Pro-Opiomelanocortin
- Sirtuin 1
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Topics |
- Animals
- Energy Metabolism
(physiology)
- Forkhead Transcription Factors
- Hypothalamus
(metabolism)
- Insulin Resistance
- Male
- Mice
- Mice, Knockout
- Neurons
(metabolism)
- Obesity
(prevention & control)
- Pro-Opiomelanocortin
(metabolism)
- Signal Transduction
(genetics)
- Sirtuin 1
(metabolism)
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