Vitreoretinal lymphoma versus uveitis: cytokine profile and correlations.

Abstract

PURPOSE:

To compare the cytokine spectrum of vitreoretinal lymphoma to uveitis and correlate cytokine concentrations with disease activity.

METHODS:

Retrospective case series of 10 patients with vitreoretinal lymphoma and 7 patients with uveitis. Aqueous humor concentration of IFN-γ, TNF-α, TNF-β, IL-1ra, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, MCP-1, G-CSF, GM-CSF, and VEGF-A was determined using a bead-based assay (Luminex). Variance between groups, correlation coefficients, and longitudinal behavior of cytokines were analyzed.

RESULTS:

No statistically significant difference in cytokines was found when comparing groups. IL-10 was positively correlated with IL-6 and MCP-1. IL-6 was positively correlated with G-CSF, IL-1ra, IL-8, and IL-10. A relationship between concentration of any cytokine, aside from IL-10, and disease activity was not found.

CONCLUSION:

IL-10 and IL-6 are good immunologic markers to be used as complementary diagnostic tools. IL-10 is the only IL that could be used for monitoring purposes.

• Authors: Juline N Caraballo, Melissa R Snyder, Patrick B Johnston, Brian P O Neill, Harish Raja, Joseph G Balsanek, Brian E Peters, Jose S Pulido
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) Vol. 22 Issue 1 Pg. 34-41 (Feb 2014) ISSN: 1744-5078 [Electronic] England
• PMID: 24490677 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Cytokines

Topics

• Aqueous Humor (metabolism)
• Biomarkers (metabolism)
• Cytokines (metabolism)
• Eye Neoplasms (diagnosis, metabolism)
• Humans
• Immunoassay
• Lymphoma, B-Cell (diagnosis, metabolism)
• Retinal Neoplasms (diagnosis, metabolism)
• Retrospective Studies
• Uveitis (diagnosis, metabolism)
• Vitreous Body (pathology)