Abstract | BACKGROUND: METHODS: 40 ESRD patients treated with hemodialysis (HD) in Gulhane School of Medicine (20 with T2DM) and 32 controls (17 with T2DM, 15 healthy controls) were included in the study. Plasma and EM FA concentrations were measured by gas chromatography-flame ionization detector (GC-FID). RESULTS: Plasma and EM palmitic acid (PA) and stearic acid (SA) levels were significantly higher in T2DM patients compared to controls (p=0.040 and p=0.002 for plasma, p=0.001 and p=0.010 for EM, respectively). EM docosahexaenoic acid (DHA) levels were also significantly lower in patients with ESRD+T2DM and ESRD compared to controls (p=0.004 and p=0.037, respectively). CONCLUSIONS: Patients with insulin resistance display a pattern of high long chain saturated FAs (PA, SA and arachidic acids). However, while there are no recognized standards for normal EM DHA content, decreased levels of EM DHA in ESRD patient groups (groups 1 and 2) suggest that there may be reduced endogenous synthesis of DHA in HD subjects, due to the decreased functionality of desaturase and elongase enzymes. Because membrane PUFA content affects membrane fluidity and cell signaling, these findings are worthy of further investigation.
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Authors | Erdim Sertoglu, Ismail Kurt, Serkan Tapan, Metin Uyanik, Muhittin A Serdar, Huseyin Kayadibi, Saad El-Fawaeir |
Journal | Chemistry and physics of lipids
(Chem Phys Lipids)
Vol. 178
Pg. 11-7
(Feb 2014)
ISSN: 1873-2941 [Electronic] Ireland |
PMID | 24384240
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Fatty Acids
- Stearic Acids
- Docosahexaenoic Acids
- Palmitic Acid
- stearic acid
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Topics |
- Adult
- Cell Membrane
(chemistry)
- Diabetes Mellitus, Type 2
(metabolism, pathology)
- Docosahexaenoic Acids
(metabolism)
- Erythrocyte Membrane
(chemistry)
- Fatty Acids
(metabolism)
- Female
- Humans
- Kidney Failure, Chronic
(metabolism, pathology)
- Male
- Middle Aged
- Palmitic Acid
(metabolism)
- Stearic Acids
(metabolism)
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