Abstract | OBJECTIVE: Literature favours the in vitro neuroprotective role of caffeic acid, a naturally derived polyphenolic compound. This study was aimed to investigate the role of caffeic acid in experimental model of Alzheimer's disease. METHODS: KEY FINDINGS: CONCLUSION: These findings suggest the antidementia activity of caffeic acid against AlCl3 -induced dementia in rats. The outcome of present study offers a wider scope to screen caffeic acid against neurodegeneration associated disorders.
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Authors | Kafeel A Khan, Nitesh Kumar, Pawan G Nayak, Madhavan Nampoothiri, Rekha R Shenoy, Nandakumar Krishnadas, C Mallikarjuna Rao, Jayesh Mudgal |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 65
Issue 12
Pg. 1745-52
(Dec 2013)
ISSN: 2042-7158 [Electronic] England |
PMID | 24236984
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 Royal Pharmaceutical Society. |
Chemical References |
- Aluminum Compounds
- Caffeic Acids
- Chlorides
- Cholinesterase Inhibitors
- Nitrites
- Phenylcarbamates
- Aluminum Chloride
- Rivastigmine
- caffeic acid
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Topics |
- Aluminum Chloride
- Aluminum Compounds
(toxicity)
- Animals
- Caffeic Acids
(pharmacology)
- Chlorides
(toxicity)
- Cholinesterase Inhibitors
(pharmacology)
- Dementia
(chemically induced, metabolism, prevention & control)
- Male
- Nitrites
(analysis)
- Phenylcarbamates
(pharmacology)
- Rats
- Rats, Wistar
- Rivastigmine
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